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RNA-binding proteins switch gears to drive alternative splicing in neurons

Nature Structural & Molecular Biology volume 14, pages 577–579 (2007)Cite this article

A new study reveals that cells naturally switch from expressing one polypyrimidine tract–binding protein (PTB) to a highly similar family member, nPTB, during the development of neurons, and shows that PTB itself regulates this transition. Ensembles of coregulated exons simultaneously change their splicing patterns, suggesting that this phenomenon could potentially mediate widespread changes in proteins composed of modular functional domains, thus driving neuronal phenotypes or disfavoring non-neuronal ones.

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Figure 1: PTB switches to nPTB during neuronal, but not glial cell, development to induce changes in the splicing patterns of ensembles of responsive exons.
Figure 2: PTB cross-regulates nPTB in neural progenitor cells.

References

  1. Lipscombe, D. Curr. Opin. Neurobiol. 15, 358–363 (2005).

    Article  CAS  Google Scholar 

  2. Boutz, P.L. et al. Genes Dev. 21, 1636–1652 (2007).

    Article  CAS  Google Scholar 

  3. Garcia-Blanco, M.A., Jamison, S.F. & Sharp, P.A. Genes Dev. 3 12A, 1874–1886 (1989).

    Article  CAS  Google Scholar 

  4. Patton, J.G., Mayer, S.A., Tempst, P. & Nadal-Ginard, B. Genes Dev. 5, 1237–1251 (1991).

    Article  CAS  Google Scholar 

  5. Polydorides, A.D., Okano, H.J., Yang, Y.Y., Stefani, G. & Darnell, R.B. Proc. Natl. Acad. Sci. USA 97, 6350–6355 (2000).

    Article  CAS  Google Scholar 

  6. Markovtsov, V. et al. Mol. Cell. Biol. 20, 7463–7479 (2000).

    Article  CAS  Google Scholar 

  7. Wollerton, M.C., Gooding, C., Wagner, E.J., Garcia-Blanco, M.A. & Smith, C.W. Mol. Cell 13, 91–100 (2004).

    Article  CAS  Google Scholar 

  8. Zhu, B., Ramachandran, B. & Gulick, T. J. Biol. Chem. 280, 28749–28760 (2005)

    Article  CAS  Google Scholar 

  9. Lim, L.P. et al. Nature 433, 769–773 (2005).

    Article  CAS  Google Scholar 

  10. Boutz, P.L., Chawla, G., Stoilov, P. & Black, D.L. Genes Dev. 21, 71–84 (2007).

    Article  CAS  Google Scholar 

  11. Muotri, A.R. & Gage, F.H. Nature 441, 1087–1093 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Paula J. Grabowski is in the Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, Pennsylvania 15221, USA. pag4@pitt.edu,

    Paula J Grabowski

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  1. Paula J Grabowski
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The author declares no competing financial interests.

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Grabowski, P. RNA-binding proteins switch gears to drive alternative splicing in neurons. Nat Struct Mol Biol 14, 577–579 (2007). https://doi.org/10.1038/nsmb0707-577

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