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Visualizing the twists and turns of a molecular chaperone

Nature Structural & Molecular Biology volume 16, pages 235–236 (2009)Cite this article

Intermediate conformations of the Hsp90 ATPase cycle have been identified in solution by fluorescence resonance energy transfer, and the impact of nucleotides and of modulatory cochaperones has been visualized in real time.

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Figure 1: Hsp90 chaperone cycle.

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Authors and Affiliations

  1. Len Neckers, Shinji Tsutsumi and Mehdi Mollapour are in the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. len@helix.nih.gov,

    Len Neckers, Shinji Tsutsumi & Mehdi Mollapour

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  1. Len Neckers
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  2. Shinji Tsutsumi
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  3. Mehdi Mollapour
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Neckers, L., Tsutsumi, S. & Mollapour, M. Visualizing the twists and turns of a molecular chaperone. Nat Struct Mol Biol 16, 235–236 (2009). https://doi.org/10.1038/nsmb0309-235

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