Regulation of integrin activity is critical for human health, and the steps mediating integrin activation are well established. In contrast, the counteracting mechanisms of inactivation are less understood. An integrin inhibitor, filamin, is shown to stabilize the integrin resting state by bondage of the cytoplasmic domains of the integrin heterodimer, thus providing evidence of a new mechanism for integrin retention in the inactive state.
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De Franceschi, N., Ivaska, J. Integrin bondage: filamin takes control. Nat Struct Mol Biol 22, 355–357 (2015). https://doi.org/10.1038/nsmb.3024
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DOI: https://doi.org/10.1038/nsmb.3024
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