Structural and functional analysis of WASP family cell signaling proteins shows that the same residues that are sequestered upon GTPase binding in the autoinhibited state are involved in binding to and activating Arp2/3 complex, WASP's downstream partner in the signaling cascade.
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Hitchcock-DeGregori, S. Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex. Nat Struct Mol Biol 10, 583–584 (2003). https://doi.org/10.1038/nsb0803-583
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DOI: https://doi.org/10.1038/nsb0803-583
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