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SNARE function revisited

The notion that SNARE proteins constitute the minimal machinery for intracellular membrane fusion has been accepted by many scientists. An EPR study now brings new structural data on the neuronal SNARE VAMP-2 and emphasizes the importance of rigorous evidence before a hypothesis becomes a dogma.

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Figure 1: Model of SNARE-mediated membrane fusion.
Figure 2: VAMP restriction by the membrane as visualized by EPR.

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Rizo, J. SNARE function revisited. Nat Struct Mol Biol 10, 417–419 (2003). https://doi.org/10.1038/nsb0603-417

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