Joint injury represents a major risk factor for the development of osteoarthritis, but a link between severity of injury and the level of cartilage damage is difficult to test in humans. However, promising advances in our understanding of this relationship have been made with the aid of animal models of joint injury.
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Pritzker, K. Joint instability and OA: do animal models provide insights?. Nat Rev Rheumatol 7, 444–445 (2011). https://doi.org/10.1038/nrrheum.2011.104
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DOI: https://doi.org/10.1038/nrrheum.2011.104
