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Stroke

Risk assessment to prevent recurrence after mild stroke or TIA

Stroke has a heavy socioeconomic burden. A subset of patients with transient or nondisabling cerebral ischaemic events will experience recurrent stroke, leading to permanent deficits. Two new studies tackle the challenge of identifying the patients most at risk for recurrent stroke via examination of radiological and serum biomarkers.

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References

  1. Rothwell, P. M. & Warlow, C. P. Timing of TIAs preceding stroke: time window for prevention is very short. Neurology 64, 817–820 (2005).

    Article  PubMed  Google Scholar 

  2. Rothwell, P. M. et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 370, 1432–1442 (2007).

    Article  PubMed  Google Scholar 

  3. Coutts, S. B. et al. What causes disability after transient ischemic attack and minor stroke? Results from the CT and MRI in the triage of TIA and minor cerebrovascular events to identify high risk patients (CATCH) study. Stroke 43, 3018–3022 (2012).

    Article  PubMed  Google Scholar 

  4. Johnston, S. C. et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 369, 283–292 (2007).

    Article  PubMed  Google Scholar 

  5. Merwick, A. et al. Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study. Lancet Neurol. 9, 1060–1069 (2010).

    Article  PubMed  Google Scholar 

  6. Wasserman, J. K. et al. Computed tomography identifies patients at high risk for stroke after transient ischemic attack/nondisabling stroke. Prospective, multicenter cohort study. Stroke 46, 114–119 (2015).

    Article  PubMed  Google Scholar 

  7. Jové, M. et al. Metabolomics predicts stroke recurrence after transient ischemic attack. Neurology 84, 36–45 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Krol, A. L. et al. Incidence of radiocontrast nephropathy in patients undergoing acute stroke computed tomography angiography. Stroke 38, 2364–2366 (2007).

    Article  PubMed  Google Scholar 

  9. Poisson, S. N. et al. Intracranial large vessel occlusion as a predictor of decline in functional status after transient ischemic attack. Stroke 42, 44–47 (2011).

    Article  PubMed  Google Scholar 

  10. Lavallée, P. C. et al. A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects. Lancet Neurol. 6, 953–960 (2007).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

S.B.C. receives salary support from Alberta Innovates–Health Solutions and has received a Pfizer Cardiovascular award and grant funding from the Heart and Stroke Foundation of Canada, Genome Canada, Canadian Institute of Health Research.

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Correspondence to Shelagh B. Coutts.

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The authors declare no competing financial interests.

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Wasserman, J. K. et al. Stroke 46, 114–119 (2015) | Jové, M. et al. Neurology 84, 36–45 (2015)

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Yu, A., Coutts, S. Risk assessment to prevent recurrence after mild stroke or TIA. Nat Rev Neurol 11, 131–133 (2015). https://doi.org/10.1038/nrneurol.2015.16

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