Abstract

The high-affinity Fc receptor for IgE (FcRI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of FcRI. The first area relates to FcRI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by FcRI; and the third area relates to the accumulated evidence for the tight control of FcRI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.

Author affiliations

1. Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine 945, 71 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA.

Correspondence to: Stefan Kraft¹ Email: jkinet@bidmc.harvard.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.