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Does lactate sustain brain metabolism during hypoglycaemia?

Nature Reviews Endocrinology volume 9, pages 386–387 (2013)Cite this article

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At very low glucose levels, the cognitive function of patients with diabetes mellitus and recurrent iatrogenic hypoglycaemia is often better than that of hypoglycaemia-naive individuals. A new study shows that the brain adapts to recurrent hypoglycaemia by increasing uptake of glucose and lactate, with preferential shuttling of glucose to neurons.

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Authors and Affiliations

  1. Department of Medicine, University of Minnesota, MMC 101, 420 Delaware Street South East, Minneapolis, 55455, MN, USA

    Elizabeth R. Seaquist

  2. Center for Magnetic Resonance Research, University of Minnesota, 2021 6th Street South East, Minneapolis, 55455, MN, USA

    Gülin Öz

Authors
  1. Elizabeth R. Seaquist
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  2. Gülin Öz
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Correspondence to Elizabeth R. Seaquist.

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The authors declare no competing financial interests.

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Seaquist, E., Öz, G. Does lactate sustain brain metabolism during hypoglycaemia?. Nat Rev Endocrinol 9, 386–387 (2013). https://doi.org/10.1038/nrendo.2013.104

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