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Hematology

ATG and Newton's third law of motion

Patients with hematological malignancies have a risk of developing graft-versus-host disease (GVHD) following allogeneic hematopoietic stem-cell transplantation. The addition of ATG to prophylaxis regimens decreases the incidence of GVHD without compromising overall survival in these patients.

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References

  1. Finke, J. et al. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncol. 10, 855–864 (2009).

    Article  CAS  Google Scholar 

  2. Mohty, M. Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond. Leukemia 21, 1387–1394 (2007).

    Article  CAS  Google Scholar 

  3. Cornelissen, J. J. et al. A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies. Exp. Hematol. 31, 855–864 (2003).

    Article  CAS  Google Scholar 

  4. Cutler, C. & Antin, J. H. Peripheral blood stem cells for allogeneic transplantation: a review. Stem Cells 19, 108–117 (2001).

    Article  CAS  Google Scholar 

  5. Bacigalupo, A. et al. Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood 98, 2942–2947 (2001).

    Article  CAS  Google Scholar 

  6. Wagner, J. E., Thompson, J. S., Carter, S. L. & Kernan, N. A. Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II–III trial. Lancet 366, 733–741 (2005).

    Article  CAS  Google Scholar 

  7. Gross, T. G. et al. B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome. Bone Marrow Transplant. 23, 251–258 (1999).

    Article  CAS  Google Scholar 

  8. van Esser, J. W. et al. Prevention of Epstein–Barr virus—lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation. Blood 99, 4364–4369 (2002).

    Article  CAS  Google Scholar 

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Brunstein, C. ATG and Newton's third law of motion. Nat Rev Clin Oncol 7, 9–10 (2010). https://doi.org/10.1038/nrclinonc.2009.192

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