Nature Neuroscience
- 9, 1362 - 1363 (2006)
Published online: 1 October 2006; | doi:10.1038/nn1780
There is a Corrigendum (February 2007) associated with this Brief Communication.
Capacity for 5-HT1A–mediated autoregulation predicts amygdala reactivityP M Fisher1, C C Meltzer1, 2, 4, S K Ziolko3, J C Price3 & A R Hariri11
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. 2
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. 3
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. 4
Present address: Department of Radiology, Emory University, Atlanta, Georgia 30322, USA.
Correspondence should be addressed to A R Hariri haririar@upmc.edu We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level–dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30–44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
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