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Myosin-VIIa and transduction channel tension

Hair cells of the ear transduce sound via a mechanical link between hair bundle movement and channel gating, which is under tension at rest. A new paper reports that myosin-VIIa is critical for maintaining resting force on the link, explaining why mutations of this gene cause deafness.

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Figure 1: Loss of resting tension deafens mice lacking myosin-VIIa.

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Gillespie, P. Myosin-VIIa and transduction channel tension. Nat Neurosci 5, 3–4 (2002). https://doi.org/10.1038/nn0102-3

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