Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

A targeted approach to cancer imaging and therapy

Nature Materials volume 13, pages 110–115 (2014)Cite this article

Subjects

Nanoparticle-based imaging plays a crucial role in cancer diagnosis and treatment. Here, we discuss the modalities used for molecular imaging of the tumour microenvironment and image-guided interventions including drug delivery, surgery and ablation therapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Examples of nanoparticles in molecular-cellular imaging.
Figure 2: Image-guided minimally invasive tumour ablation therapy mediated by molecularly targeted multifunctional nanoparticles.

References

  1. Hamburg, M. A. & Collins, F. S. N. Engl. J. Med. 363, 301–304 (2010).

    CAS  Google Scholar 

  2. Zámečníkova, A. Expert Opin. Drug Discov. 9, 77–92 (2014).

    Google Scholar 

  3. Mankoff, D. A. J. Nucl. Med. 48, 18N–21N (2007).

    Google Scholar 

  4. Blasberg, R. & Piwnica-Worms, D. Clin. Cancer. Res. 18, 631–637 (2012).

    Google Scholar 

  5. Pysz, M. A., Gambhir, S. S. & Willmann, J. K. Clin. Radiol. 65, 500–516 (2010).

    CAS  Google Scholar 

  6. Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T. & Josephson, L. Nature Biotechnol. 23, 1418–1423 (2005).

    CAS  Google Scholar 

  7. Vera, D. R., Wallace, A. M., Hoh, C. K. & Mattrey, R. F. J. Nucl. Med. 42, 951–959 (2001).

    CAS  Google Scholar 

  8. Sondak, V. et al. Ann. Surg. Oncol. 20, 680–688 (2013).

    Google Scholar 

  9. Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

    Article  CAS  Google Scholar 

  10. Hurwitz, H. et al. N. Engl. J. Med. 350, 2335–2342 (2004).

    CAS  Google Scholar 

  11. Morales-Avila, E. et al. Bioconjug. Chem. 22, 913–922 (2011).

    CAS  Google Scholar 

  12. Yang, X. et al. Biomaterials 32, 4151–4160 (2011).

    CAS  Google Scholar 

  13. Chen, F. et al. ACS Nano 7, 9027–9039 (2013).

    CAS  Google Scholar 

  14. Pochon, S. et al. Invest. Radiol. 45, 89–95 (2010).

    CAS  Google Scholar 

  15. Deshpande, N., Ren, Y., Foygel, K., Rosenberg, J. & Willmann, J. K. Radiology 258, 804–811 (2011).

    Google Scholar 

  16. Kiessling, F., Fokong, S., Koczera, P., Lederle, W. & Lammers, T. J. Nucl. Med. 53, 345–348 (2012).

    CAS  Google Scholar 

  17. Lu, W. et al. Cancer. Res. 71, 6116–6121 (2011).

    CAS  Google Scholar 

  18. Schmieder, A. H. et al. Radiology 268, 470–480 (2013).

    Google Scholar 

  19. Bolley, J. et al. Nanoscale 5, 11478–11489 (2013).

    CAS  Google Scholar 

  20. Corot, C. & Warlin, D. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 5, 411–422 (2013).

    CAS  Google Scholar 

  21. Hak, S. et al. Angiogenesis 17, 93–107 (2014).

    CAS  Google Scholar 

  22. Brabletz, T., Lyden, D., Steeg, P. S. & Werb, Z. Nature Med. 19, 1104–1109 (2013).

    CAS  Google Scholar 

  23. Weissleder, R., Nahrendorf, M. & Pittet, M. Nature Mater. 13, 125–138 (2014).

    CAS  Google Scholar 

  24. Melancon, M. P. et al. Biomaterials 31, 6567–6573 (2010).

    CAS  Google Scholar 

  25. Lanza, G. M. et al. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 6, 1–14 (2013).

    Google Scholar 

  26. Rosen, J. E., Chan, L., Shieh, D.-B. & Gu, F. X. Nanomed. Nanotechnol. Biol. 8, 275–290 (2012).

    CAS  Google Scholar 

  27. Wu, L., Cao, Y., Liao, C., Huang, J. & Gao, F. Eur. J. Radiol. 80, 582–589 (2011).

    Google Scholar 

  28. Harisinghani, M. G. et al. N. Engl. J. Med. 348, 2491–2499 (2003).

    Google Scholar 

  29. Wang, Y.-X. J. Quant. Imaging. Med. Surg. 1, 35–40 (2011).

    Google Scholar 

  30. Ferrari, M. Nature Rev. Cancer 5, 161–171 (2005).

    CAS  Google Scholar 

  31. Chauhan, V. & Jain, R. K. Nature Mater. 12, 958–962 (2013).

    CAS  Google Scholar 

  32. Choi, H. S. et al. Nature Biotechnol. 25, 1165–1170 (2007).

    CAS  Google Scholar 

  33. Kim, B. H. et al. J. Am. Chem. Soc. 133, 12624–12631 (2011).

    CAS  Google Scholar 

  34. Choi, H. S. & Frangioni, J. V. Mol. Imaging 9, 291–310 (2010).

    CAS  Google Scholar 

  35. Lee, C.-M. et al. J. Nucl. Med. 54, 1974–1980 (2013).

    CAS  Google Scholar 

  36. Unnikrishnan, S. & Klibanov, A. L. Am. J. Roentgenol. 199, 292–299 (2012).

    Google Scholar 

  37. Sheeran, P. S. & Dayton, P. A. Curr. Pharm. Des. 18, 2152–2165 (2012).

    CAS  Google Scholar 

  38. Sheeran, P. S., Luois, S. H., Mullin, L. B., Matsunaga, T. O. & Dayton, P. A. Biomaterials 33, 3262–3269 (2012).

    CAS  Google Scholar 

  39. Von Maltzahn, G. et al. Nature Mater. 10, 545–552 (2011).

    CAS  Google Scholar 

  40. Zhang, H.-W. et al. Biomaterials 35, 356–367 (2014).

    Google Scholar 

  41. Cassidy, M. C., Chan, H. R., Ross, B. D., Bhattacharya, P. K. & Marcus, C. M. Nature Nanotech. 8, 363–368 (2013).

    CAS  Google Scholar 

  42. Cheng, Z., Al Zaki, A., Hui, J. Z., Muzykantov, V. R. & Tsourkas, A. Science 338, 903–910 (2012).

    CAS  Google Scholar 

  43. Orosco, R. K., Tsien, R. Y. & Nguyen, Q. T. IEEE Rev. Biomed. Eng. 6, 178–187 (2013).

    Google Scholar 

  44. Stummer, W. et al. Lancet Oncol. 7, 392–401 (2006).

    CAS  Google Scholar 

  45. Sakuma, S. et al. Eur. J. Pharm. Biopharm. 79, 537–543 (2011).

    CAS  Google Scholar 

  46. Garai, E. et al. J. Biomed. Optics 18, 096008 (2013).

    Google Scholar 

  47. Jokerst, J. V., Cole, A. J., Van de Sompel, D. & Gambhir, S. S. ACS Nano 6, 10366–10377 (2012).

    CAS  Google Scholar 

  48. Zhang, R. et al. J. Nucl. Med. 52, 958–964 (2011).

    CAS  Google Scholar 

  49. Ali, Z. et al. Anal. Chem. 83, 2877–2882 (2011).

    CAS  Google Scholar 

  50. Cha, E.-J. et al. J. Control. Release 155, 152–158 (2011).

    CAS  Google Scholar 

  51. Olson, E. S. et al. Proc. Natl Acad. Sci. USA 107, 4311–4316 (2010).

    CAS  Google Scholar 

  52. Kircher, M. F. et al. Nature Med. 18, 829–834 (2012).

    CAS  Google Scholar 

  53. Ibsen, S., Schutt, C. E. & Esener, S. Drug Des. Devel. Ther. 7, 375–388 (2013).

    CAS  Google Scholar 

  54. Chen, K.-J. et al. ACS Nano 7, 438–446 (2012).

    Google Scholar 

  55. You, J. et al. Cancer. Res. 72, 4777–4786 (2012).

    CAS  Google Scholar 

  56. You, J. et al. J. Control. Release 158, 319–328 (2012).

    CAS  Google Scholar 

  57. Hong, C. W., Libutti, S. K. & Wood, B. J. Curr. Oncol. 20, e274–e277 (2013).

    CAS  Google Scholar 

  58. Melancon, M. P. et al. Invest. Radiol. 46, 132–140 (2011).

    Google Scholar 

  59. Hijnen, N. M., de Vries, A., Nicolay, K. & Grüll, H. Contrast Media Mol. Imaging 7, 214–222 (2012).

    CAS  Google Scholar 

  60. Lee, H. J. et al. J. Control. Release 172, 152–158 (2013).

    CAS  Google Scholar 

  61. Zou, P., Chen, H., Paholak, H. J. & Sun, D. Mol. Pharm. 10, 4185–4194 (2013).

    CAS  Google Scholar 

  62. Langereis, S. et al. J. Am. Chem. Soc. 131, 1380–1381 (2009).

    CAS  Google Scholar 

  63. Rieke, V. & Butts Pauly, K. J. Magn. Reson. Imaging 27, 376–390 (2008).

    Google Scholar 

  64. Roizin-Towle, L. & Pirro, J. P. Int. J. Radiat. Oncol. Biol. Phys. 20, 751–756 (1991).

    CAS  Google Scholar 

  65. Dewhirst, M. W., Viglianti, B. L., Lora-Michiels, M., Hanson, M. & Hoopes, P. J. Int. J. Hyperthermia 19, 267–294 (2003).

    CAS  Google Scholar 

  66. Sapareto, S. A. & Dewey, W. C. Int. J. Radiat. Oncol. Biol. Phys. 10, 787–800 (1984).

    CAS  Google Scholar 

  67. Fahrenholtz, S. J., Stafford, R. J., Maier, F., Hazle, J. D. & Fuentes, D. Int. J. Hyperthermia 29, 324–335 (2013).

    Google Scholar 

  68. Gasselhuber, A. et al. Int. J. Hyperthermia 26, 499–513 (2010).

    CAS  Google Scholar 

  69. Dothager, R. S. & Piwnica-Worms, D. Cancer. Res. 71, 5611–5615 (2011).

    CAS  Google Scholar 

Download references

Acknowledgements

I would like to thank Dr. David Piwnica-Worms for helpful discussions. This work was supported in part by the National Cancer Institute (U54CA151668 and R01CA119387), the Viragh Family Foundation and the John S. Dunn Foundation.

Author information

Authors and Affiliations

  1. Chun Li is in the Department of Cancer Systems Imaging—Unit 59, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA,

    Chun Li

Authors
  1. Chun Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chun Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, C. A targeted approach to cancer imaging and therapy. Nature Mater 13, 110–115 (2014). https://doi.org/10.1038/nmat3877

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat3877

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer