Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Optical biopsy and imaging using optical coherence tomography

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Huang, D. et al. Optical coherence tomography. Science 254, 1178–1181 (1991).

    Article  CAS  Google Scholar 

  2. Swanson, E.A. et al. In vivo retinal imaging by optical coherence tomography. Opt. Lett. 18, 1864–1866, (1993).

    Article  CAS  Google Scholar 

  3. Youngquist, R.C., Carr, S. & Davies, D.E.N. Optical coherence-domain reflectometry: A new optical evaluation technique. Opt. Lett. 12, 158–160, (1987).

    Article  CAS  Google Scholar 

  4. Takada, K., Yokohama, I., Chida, K. & Noda, J. New measurement system for fault location in optical waveguide devices based on an interferometric technique. Appl. Opt. 26, 1603–1606 (1987).

    Article  CAS  Google Scholar 

  5. Gilgen, H.H. et al. Submillimeter optical reflectometry. IEEE J. Lightwave Technol. 8, 1225–1233 (1989).

    Article  Google Scholar 

  6. Fercher, A.F., Mengedoht, K. & Werner, W. Eye-length measurement by interferometry with partially coherent light. Opt. Lett. 13, 1867–1869 (1988).

    Article  Google Scholar 

  7. Hitzenberger, C.K., Drexler, W. & Fercher, A.F. Measurement of corneal thickness by laser doppler interferometry. Invest. Ophthalmol. vis. Sci. 33, 98–103 (1992).

    CAS  PubMed  Google Scholar 

  8. Clivaz, X., Marquis-Weible, F. & Salath≥, R.-P. in European Biomedical Optics Conference, SPIE Proc. 2083–2092 (1994).

    Google Scholar 

  9. Bouma, B.E. et al. High resolution optical coherence tomographic imaging using a modelocked Ti:Al2O3 laser source. Opt. Lett. 20, 1486–1488 (1995).

    Article  CAS  Google Scholar 

  10. Izatt, J.A. et al. Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Arch. Ophthalmol. 112, 1584–1589 (1994).

    Article  CAS  Google Scholar 

  11. Hee, M.R. et al. Optical coherence tomography of the human retina. Arch. Ophthalmol. 113, 325–332 (1995).

    Article  CAS  Google Scholar 

  12. Puliafito, C.A. et al. Imaging of macular diseases with optical coherence tomography. Ophthalmology 102, 217–229 (1995).

    Article  CAS  Google Scholar 

  13. Puliafito, C.A., Hee, M.R., Schuman, J.S. & Fujimoto, J.G. in Optical Coherence Tomography of Ocular Diseases (Slack, Thorofare, New Jersey, in the press).

  14. Clivaz, W., Marquis-Weible, F., Salathe, R.P., Novak, R.P. & Gilgen, H.H. High-resolution reflectometry in biological tissues. Opt. Lett. 17, 4–6 (1992).

    Article  CAS  Google Scholar 

  15. Schmitt, J.M., Knuttel, A. & Bonner, R.F. Measurements of optical properties of biological tissues by low-coherence reflectometry. Appl. Opt. 32, 6032–6042 (1993).

    Article  CAS  Google Scholar 

  16. Schmitt, J.M., Knuttel, A., Yadlowsky, M. & Eckhaus, M.A. Optical-coherence tomography of a dense tissue: Statistics of attenuation and backscattering. Phys. Med. Biol. 39, 1705–1720 (1994).

    Article  CAS  Google Scholar 

  17. Herrick, J.B. Clinical features of sudden obstruction of the coronary arteries. JAMA 59, 2015–2020 (1912).

    Article  Google Scholar 

  18. Richardson, P.D., Davies, M.J. & Born, G.V.R. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet i, 941–944 (1989).

    Article  Google Scholar 

  19. Falk, E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis, characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br. Heart J. 50, 127–134 (1983).

    Article  CAS  Google Scholar 

  20. Davies, M.J. & Thomas, A.C. Plaque fissuring — the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br. Heart J. 53, 363–373, (1983).

    Article  Google Scholar 

  21. Fuster, V., Badimon, L., Badimon, J.J. & Chesebro, J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes. New Engl. J. Med. 326, 242–250 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fujimoto, J., Brezinski, M., Tearney, G. et al. Optical biopsy and imaging using optical coherence tomography. Nat Med 1, 970–972 (1995). https://doi.org/10.1038/nm0995-970

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0995-970

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing