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Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

Nature Medicine volume 4, pages 963–966 (1998)Cite this article

Abstract

Substitutive therapy using fetal striatal grafts in animal models of Huntington disease (HD) have already demonstrated obvious beneficial effects on motor indices1. Using a new phenotypic model of HD recently designed in primates2,3, we demonstrate here complete and persistent recovery in a frontal-type cognitive task two to five months after intrastriatal allografting. The striatal allografts also reduce the occurence of dystonia, a major abnormal movement associated with HD. These results show the capacity of fetal neurons to provide a renewed substrate for both cognitive and motor systems in the lesioned adult brain. They also support the use of neural transplantation as a potential therapy for HD.

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Author notes

  1. Philippe Hantraye: Correspondence should be addressed to P.H.

Authors and Affiliations

  1. CEA CNRS URA 2210, Service Hospitaller Frédéric Joliot, CEA, DSV, DRM, 4 place du Général Leclerc, 91401, Orsay cedex, France

    Stéphane Palfi, Françoise Condé, Emmanuel Brouillet, Caroline Dautry, Vincent Mittoux, Anne Chibois & Philippe Hantraye

  2. INSERM U-421, IM3, Faculté de Médecine, 8 rue du Général Sarrail, 94010, Créteil cedex, France

    Danielle Riche & Marc Peschanski

Authors
  1. Stéphane Palfi
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  2. Françoise Condé
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  3. Danielle Riche
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  4. Emmanuel Brouillet
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  5. Caroline Dautry
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  6. Vincent Mittoux
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  7. Anne Chibois
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  8. Marc Peschanski
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  9. Philippe Hantraye
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Palfi, S., Condé, F., Riche, D. et al. Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease. Nat Med 4, 963–966 (1998). https://doi.org/10.1038/nm0898-963

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