Article PDF
References
Thompson, W.D., Stirk, C.M., Melvin, W.T. & Smith, E.B. Plasmin, fibrin degradation and angiogenesis. Nature Med. 2, 493 (1996).
Rømer, J. et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med. 2, 287–292 (1996).
Bugge, T.H., Flick, M.J., Daugherty, C. C. & Degen, J.L. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 9, 794–807 (1995).
Suh, T. et al. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev. 9, 2020–2033 (1995).
Kwaan, H.C. & Astrup, T. Tissue repair in presence of locally applied inhibitors of fibrinolysis. Exp. Molec. Pathol. 11, 82–88 (1969).
Bränsted, S. et al. Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. Eur. Surg. Res. 12, 12 (1980).
Martin, P. et al. Actin cables and epidermal movement in embryonic wound healing. Nature 360, 179–183 (1992).
Stecher, V.J. & Sorkin, E. The chemotactic activity of fibrin lysis products. Int. Arch. Allergy 43, 879–886 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rømer, J., Bugge, T., Pyke, C. et al. Plasminogen and wound healing. Nat Med 2, 725 (1996). https://doi.org/10.1038/nm0796-725a
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0796-725a
This article is cited by
-
Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds
Cell Death & Disease (2020)
-
Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression
Cellular and Molecular Life Sciences (2015)
-
Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARγ signaling as potential mechanism for the negative relationships between immune response and lipid metabolism
BMC Genomics (2009)