Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to the Editor
  • Published:

A role for GAPDH in apoptosis and neurodegeneration

Nature Medicine volume 2, pages 609–610 (1996)Cite this article

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Burke, J.R. et al. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2, 347–350 (1996).

    Article  CAS  Google Scholar 

  2. Ishitani, R. et al. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture. J. Neurochem. 66, 928–935 (1996).

    Article  CAS  Google Scholar 

  3. Ishitani, R. et al. An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebro-cortical neurons in culture. J. Pharmacol. Exp. Ther. (in the press).

  4. Portera-Cailliau, C., Hedreen, J.C., Price, D.L. & Koliatsos, V.E. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J. Neurosci. 15, 3775–3787 (1995).

    Article  CAS  Google Scholar 

  5. Sunaga, K., Takahashi, H., Chuang, D.-M. & Ishitani, R. Glyceraldehyde-3-phosphate dehydrogenase is over-expressed during apoptotic death of neuronal cultures and is recognized by a monoclonal antibody against amyloid plaques from Alzheimer's brain. Neurosci. Lett. 200, 133–136 (1995).

    Article  CAS  Google Scholar 

  6. Stott, K., Blackburn, J.M., Butler, P.J.G. & Perutz, M. Incorporation of glutamine repeats makes protein oligomerize: Implications for neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 92, 6509–6513 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Molecular Neurobiology Biological Psychiatry Branch, National Institute of Mental Health NIH, Building 10, Room 3N212, Bethesda, Maryland, 20892-1272, USA

    De-Maw Chuang

  2. Group on Cellular Neurobiology, Josai University, Sakado, Saitama, 350-02, Japan

    Ryoichi Ishitani

Authors
  1. De-Maw Chuang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ryoichi Ishitani
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chuang, DM., Ishitani, R. A role for GAPDH in apoptosis and neurodegeneration. Nat Med 2, 609–610 (1996). https://doi.org/10.1038/nm0696-609

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0696-609

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing