Approximately 5% of people that are hospitalized for any reason develop acute kidney failure, which, in some cases, progresses to a chronic condition resulting in fibrosis of the kidney and permanent changes in the organ's function. Two new studies suggest that cell cycle arrest of epithelial cells and epigenetic modifications have key roles in the switch to chronic disease (pages 535–543 and 544–550).
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Wynn, T. Fibrosis under arrest. Nat Med 16, 523–525 (2010). https://doi.org/10.1038/nm0510-523
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DOI: https://doi.org/10.1038/nm0510-523
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