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Robo4 counteracts VEGF signaling

Nature Medicine volume 14, pages 372–373 (2008)Cite this article

Robo4 expression in emerging blood vessels can neutralize signaling through the angiogenic factor vascular endothelial growth factor (VEGF) and maintain vessel integrity. The findings could lead to new therapeutic targets for angiogenesis and vascular leakage (pages 448–453).

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Figure 1: The work of Jones et al.3

Kim Caesar

References

  1. Eichmann, A., Makinen, T. & Alitalo, K. Genes Dev. 19, 1013–1021 (2005).

    Article  CAS  Google Scholar 

  2. Legg, J.A., Herbert, J.M., Clissold, P. & Bicknell, R. Angiogenesis published online, doi:10.1007/s10456-008-9100-x (9 February 2008).

    Google Scholar 

  3. Jones, C.A. et al. Nat. Med 14, 448–453 (2008).

    Article  CAS  Google Scholar 

  4. Weis, S.M. & Cheresh, D.A. Nature 437, 497–504 (2005).

    Article  CAS  Google Scholar 

  5. Casanovas, O., Hicklin, D.J., Bergers, G. & Hanahan, D. Cancer Cell 8, 299–309 (2005).

    Article  CAS  Google Scholar 

  6. Wang, B. et al. Cancer Cell 4, 19–29 (2003).

    Article  Google Scholar 

  7. Park, K.W. et al. Dev. Biol. 261, 251–267 (2003).

    Article  CAS  Google Scholar 

  8. Suchting, S., Heal, P., Tahtis, K., Stewart, L.M. & Bicknell, R. FASEB J. 19, 121–123 (2005).

    Article  CAS  Google Scholar 

  9. Bedell, V.M. et al. Proc. Natl. Acad. Sci. USA 102, 6373–6378 (2005).

    Article  CAS  Google Scholar 

  10. Sabatier, C. et al. Cell 117, 157–169 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Sara M. Weis and David A. Cheresh are in the Department of Pathology and the Moores University of California–San Diego Cancer Center, Lisette M. Acevedo, University of California, San Diego, La Jolla, California 92093-0803, USA. dcheresh@ucsd.edu,

    Lisette M Acevedo, Sara M Weis & David A Cheresh

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  1. Lisette M Acevedo
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  2. Sara M Weis
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  3. David A Cheresh
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Acevedo, L., Weis, S. & Cheresh, D. Robo4 counteracts VEGF signaling. Nat Med 14, 372–373 (2008). https://doi.org/10.1038/nm0408-372

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