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Tying up PGE2 with albumin to relieve immunosuppression in cirrhosis

Nature Medicine volume 20, pages 467–469 (2014)Cite this article

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The function of the innate immune system is suppressed in patients with acutely decompensated cirrhosis and predisposes these patients to bacterial infections. A new study shows that increased synthesis of the immunosuppressive prostaglandin PGE2 by circulating monocytes and resident macrophages and impaired hepatic synthesis of human serum albumin (HSA) are major contributors to immune suppression in cirrhosis (pages 518–523). The authors' data suggests a new avenue for therapy in acute decompensation of cirrhosis.

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Figure 1: Cirrhosis-associated immune suppression may be mediated by PGE2 and treated with albumin administration.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Vicente Arroyo is at the Liver Unit, Hospital Clinic, Centre Esther Koplowitz, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain, and at Centro de Investigación Biomédica en Red, Barcelona, Spain.,

    Vicente Arroyo

  2. and Département Hospitalo-Universitaire UNITY, Richard Moreau is at INSERM UMR S 1149, Centre de Recherche sur l'Inflammation, Paris, France, Université Paris Diderot, Faculté de Médecine, Paris, France, Service d'Hépatologie, Hôpital Beaujon, Assistance Publique–Hôpitaux de Paris, Clichy, France.,

    Richard Moreau

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  1. Vicente Arroyo
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  2. Richard Moreau
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Correspondence to Vicente Arroyo.

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V.A. has a grant from Grifols.

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Arroyo, V., Moreau, R. Tying up PGE2 with albumin to relieve immunosuppression in cirrhosis. Nat Med 20, 467–469 (2014). https://doi.org/10.1038/nm.3553

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