Complement is intricately involved in inflammatory processes, yet the mechanisms that modulate the actions of its key mediator C5a are poorly understood. A new study uncovers a molecular partnership between three neutrophil receptors in the recognition of differentially glycated immune complexes and sheds light on regulatory processes in autoimmune and inflammatory disorders (pages 1401–1406).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis
Arthritis Research & Therapy Open Access 17 January 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Blumberg, R.S., Dittel, B. & Hafler, D. Nat. Med. 18, 35–41 (2012).
Ricklin, D., Hajishengallis, G., Yang, K. & Lambris, J.D. Nat. Immunol. 11, 785–797 (2010).
Klos, A. et al. Mol. Immunol. 46, 2753–2766 (2009).
Hashimoto, M. et al. J. Exp. Med. 207, 1135–1143 (2010).
Laumonnier, Y., Schmudde, I. & Kohl, J. Curr. Allergy Asthma Rep. 11, 122–130 (2011).
Godau, J. et al. J. Immunol. 173, 3437–3445 (2004).
Karsten, C.M. et al. Nat. Med. 18, 1401–1406 (2012).
Nimmerjahn, F. & Ravetch, J.V. Nat. Rev. Immunol. 8, 34–47 (2008).
Sancho, D. & Reis e Sousa, C. Annu. Rev. Immunol. 30, 491–529 (2012).
Anthony, R.M., Wermeling, F. & Ravetch, J.V. Ann. NY Acad. Sci. 1253, 170–180 (2012).
Oefner, C.M. et al. J. Allergy Clin. Immunol. 129, 1647–1655 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Ricklin, D., Reis, E. & Lambris, J. A sweet spot to control complement-induced inflammation. Nat Med 18, 1340–1341 (2012). https://doi.org/10.1038/nm.2916
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2916
This article is cited by
-
CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis
Arthritis Research & Therapy (2015)
-
Molecular Basis for Downregulation of C5a-Mediated Inflammation by IgG1 Immune Complexes in Allergy and Asthma
Current Allergy and Asthma Reports (2013)