Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

To survive radiation injury, remember your aPCs

Nature Medicine volume 18, pages 1013–1014 (2012)Cite this article

Subjects

Acute exposure to ionizing radiation can cause lethality via severe damage to the hematopoietic system. A new study shows that infusion of the anticoagulants thrombomodulin or activated protein C reduces radiation toxicities and improves survival (pages 1123–1129).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Thrombomodulin and aPC can mitigate radiation-induced toxicity.

Katie Vicari

References

  1. Mettler, F.A. & Voelz, G.L. N. Engl. J. Med. 346, 1554–1561 (2002).

    Article  Google Scholar 

  2. Oughterson, A.W. & Warren, S. Medical Effects of the Atomic Bomb in Japan. (McGraw-Hill, New York, 1956).

    Google Scholar 

  3. Baranov, A. et al. N. Engl. J. Med. 321, 205–212 (1989).

    Article  CAS  Google Scholar 

  4. Allison, G. Report of the Commission on the Prevention of Weapons of Mass Destruction, Proliferation and Terrorism. http://belfercenter.ksg.harvard.edu/publication/18786/world_at_risk.html (2009; accessed 13 June 2012).

  5. Wasalenko, J.K. et al. Ann. Intern. Med. 140, 1037–1051 (2004).

    Article  Google Scholar 

  6. Dainiak, N. Exp. Hematol. 30, 513–528 (2002).

    Article  CAS  Google Scholar 

  7. Coleman, C.N. et al. Ann. Emerg. Med. 53, 213–222 (2009).

    Article  Google Scholar 

  8. Geiger, H. et al. Nat. Med. 18, 1123–1129 (2012).

    Article  CAS  Google Scholar 

  9. Wang, W., Nagashima, M., Schneider, M., Morser, J. & Nesheim, M. J. Biol. Chem. 275, 22942–22947 (2000).

    Article  CAS  Google Scholar 

  10. Esmon, N.L., Owen, W. & Esmon, C. J. Biol. Chem. 257, 859–864 (1982).

    CAS  Google Scholar 

  11. Mosnier, L.O., Zlokovic, B. & Griffin, J. Blood 109, 3161–3172 (2007).

    Article  CAS  Google Scholar 

  12. Weiler, H. Crit. Care Med. 38, S18–S25 (2010).

    Article  CAS  Google Scholar 

  13. Hooper, A.T. et al. Cell Stem Cell 4, 263–274 (2009).

    Article  CAS  Google Scholar 

  14. Salter, A.B. et al. Blood 113, 2104–2107 (2009).

    Article  CAS  Google Scholar 

  15. Butler, J.M. et al. Cell Stem Cell 6, 251–264 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. John P. Chute is in the Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina, USA.,

    John P Chute

Authors
  1. John P Chute
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to John P Chute.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chute, J. To survive radiation injury, remember your aPCs. Nat Med 18, 1013–1014 (2012). https://doi.org/10.1038/nm.2859

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2859

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research