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Matching SOCS with function

Overexpression studies suggest that SOCS3 is a pleiotropic negative regulator of cytokines. The generation of Socs3−/− mice indicates that SOCS3 actually functions in a remarkably specific manner.

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Figure 1: More than just an inhibitor: SOCS3 regulates the transcriptional program induced by IL-6, attenuating its immunosuppressive actions.

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References

  1. Pasare, C. & Medzhitov, R. Science 299, 1033–1036 (2003).

    Article  CAS  Google Scholar 

  2. Lang, R, et al. Nat. Immunol. 4, 546–550 (2003).

    Article  CAS  Google Scholar 

  3. Croker, B.A. et al. Nat. Immunol. 4, 540–545 (2003).

    Article  CAS  Google Scholar 

  4. Yasukawa, H. et al. Nat. Immunol. 4, 551–556 (2003).

    Article  CAS  Google Scholar 

  5. Alexander, W.S. et al. Cell 98, 597–608 (1999).

    Article  CAS  Google Scholar 

  6. Marine, J.C. et al. Cell 98, 609–616 (1999).

    Article  CAS  Google Scholar 

  7. Metcalf, D. et al. Nature 405, 1069–1073 (2000).

    Article  CAS  Google Scholar 

  8. Karp, C.L. et al. Curr. Opin. Neurol. 14, 361–368 (2001).

    Article  CAS  Google Scholar 

  9. Cacalano, N.A. et al. Nat. Cell. Biol. 3, 460–465 (2001).

    Article  CAS  Google Scholar 

  10. Astumi, T. et al. J. Exp. Med. 196, 979–990 (1997).

    Google Scholar 

Download references

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Correspondence to John J O'Shea.

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Johnston, J., O'Shea, J. Matching SOCS with function. Nat Immunol 4, 507–509 (2003). https://doi.org/10.1038/ni0603-507

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  • DOI: https://doi.org/10.1038/ni0603-507

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