News and Views
Nature Immunology 9, 457 - 459 (2008)
doi:10.1038/ni0508-457
CD3
: PeRuSing for positive selection
Jonathan S Maltzman1 & Gary A Koretzky2
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Jonathan S. Maltzman is in the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
e-mail: maltz@mail.med.upenn.edu -
Gary A. Koretzky is in the Department of Pathology and Laboratory Medicine, the Department of Medicine and the Abramson Family Cancer Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
e-mail: koretzky@mail.med.upenn.edu
Abstract
How engagement of surface T cell antigen receptors 'translates' into intracellular signal cascades remains vague. Genetic and biochemical experiments now allow modification of a model linking ligation of these receptors with CD3
and other cytoplasmic signal-transduction 'machinery'.
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