1. Andrey S. Shaw is in the Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University, St. Louis, Missouri 63110, USA. e-mail: ashaw@wustl.edu

Abstract

Naive T cells can spend hours 'sampling' dendritic cells before making a stable conjugate with a single dendritic cell. It is the antigen 'dose' that determines how long this process takes.

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