The transcription factor Nr4a1 can negatively regulate norepinephrine production in the context of neuroinflammation and thereby prevent the ensuing neuroinflammatory cascade in a mouse model of experimental autoimmune encephalomyelitis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar/Nature Publishing Group
References
Prinz, M. & Priller, J. Nat. Rev. Neurosci. 15, 300–312 (2014).
Mildner, A. et al. Brain 132, 2487–2500 (2009).
Sanders, V.M. & Kohm, A.P. Int. Rev. Neurobiol. 52, 17–41 (2002).
Shaked, I. et al. Nat. Immunol. 16, 1228–1234 (2015).
McMorrow, J.P. & Murphy, E.P. Biochem. Soc. Trans. 39, 688–693 (2011).
Hanna, R.N. et al. Nat. Immunol. 12, 778–785 (2011).
Carlin, L.M. et al. Cell 153, 362–375 (2013).
Gordon, J.W., Shaw, J.A. & Kirshenbaum, L.A. Circ. Res. 108, 1122–1132 (2011).
Raasch, J. et al. Brain 134, 1184–1198 (2011).
van Loo, G. et al. Nat. Immunol. 7, 954–961 (2006).
Slota, C., Shi, A., Chen, G., Bevans, M. & Weng, N.P. Brain Behav. Immun. 46, 168–179 (2015).
Goldmann, T. et al. Nat. Neurosci. 16, 1618–1626 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Jordão, M., Prinz, M. Nr4a1 discloses the sympathetic side of monocytes. Nat Immunol 16, 1211–1213 (2015). https://doi.org/10.1038/ni.3317
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3317
