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Act1-hsp90 heats up TH17 inflammation

Nature Immunology volume 14, pages 16–17 (2013)Cite this article

Psoriasis is associated with the TH17 subset of helper T cells. Dysregulation of interleukin 17 (IL-17) signaling leads to enhanced TH17 differentiation, more production of IL-22 and IL-22-dependent skin inflammation.

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Figure 1: Deficiency or destabilization of Act1 leads to IL-22-dependent skin inflammation.

Marina Corral

References

  1. Miossec, P. & Kolls, J.K. Nat. Rev. Drug Discov. 11, 763–776 (2012).

    Article  CAS  Google Scholar 

  2. Dudakov, J.A. et al. Science 336, 91–95 (2012).

    Article  CAS  Google Scholar 

  3. Papp, K.A. et al. N. Engl. J. Med. 366, 1181–1189 (2012).

    Article  CAS  Google Scholar 

  4. Qian, Y. et al. Nat. Immunol. 8, 247–256 (2007).

    Article  CAS  Google Scholar 

  5. Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2. Nat. Genet. 42, 985–990 (2010).

  6. Wang, C. et al. Nat. Immunol. 14, 72–81 (2013).

    Article  CAS  Google Scholar 

  7. Matsushima, Y. et al. J. Immunol. 185, 2340–2349 (2010).

    Article  CAS  Google Scholar 

  8. Zheng, Y. et al. Nature 445, 648–651 (2007).

    Article  CAS  Google Scholar 

  9. Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V.K. Annu. Rev. Immunol. 27, 485–517 (2009).

    CAS  Google Scholar 

  10. Nagata, T. et al. J. Immunol. 181, 7473–7479 (2008).

    Article  CAS  Google Scholar 

  11. Smith, E. et al. J. Immunol. 181, 1357–1364 (2008).

    Article  CAS  Google Scholar 

  12. Kleinschek, M.A. et al. J. Exp. Med. 204, 161–170 (2007).

    Article  CAS  Google Scholar 

  13. Kreindler, J.L. et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 296, L257–L266 (2009).

    Article  CAS  Google Scholar 

  14. Dorschner, R.A. et al. FASEB J. 20, 35–42 (2006).

    Article  CAS  Google Scholar 

  15. Gao, Z., Tseng, C.H., Strober, B.E., Pei, Z. & Blaser, M.J. PLoS ONE 3, e2719 (2008).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Pawan Kumar and Jay K. Kolls are with the Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.,

    Pawan Kumar & Jay K Kolls

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  1. Pawan Kumar
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  2. Jay K Kolls
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Correspondence to Jay K Kolls.

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Kumar, P., Kolls, J. Act1-hsp90 heats up TH17 inflammation. Nat Immunol 14, 16–17 (2013). https://doi.org/10.1038/ni.2498

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