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Reply to “On the design and analysis of gene expression studies in human populations”

Nature Genetics volume 39, pages 808–809 (2007)Cite this article

Spielman and Cheung reply:

In our paper1, we found that mean gene expression differed significantly between European-derived and Asian-derived populations for approximately 25% of 4,197 genes tested. For the expression phenotypes with the strongest evidence of polymorphic cis determinants, the differences in mean expression were largely explained by differences in the frequency of specific polymorphic variants.

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Figure 1: The population difference in expression of POMZP3 is accounted for by the allele frequency difference at the very closely linked SNP rs2005354.

References

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Authors and Affiliations

  1. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA

    Richard S Spielman & Vivian G Cheung

  2. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA

    Vivian G Cheung

  3. The Children's Hospital of Philadelphia, Philadelphia, 19104, Pennsylvania, USA

    Vivian G Cheung

Authors
  1. Richard S Spielman
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  2. Vivian G Cheung
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Spielman, R., Cheung, V. Reply to “On the design and analysis of gene expression studies in human populations”. Nat Genet 39, 808–809 (2007). https://doi.org/10.1038/ng0707-808

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