New studies indicate that damage to the mitochondrial genome (mtDNA) accumulates with age, specifically in the dopaminergic neurons of the substantia nigra implicated in Parkinson disease. These findings suggest that mtDNA damage is important in the decay of dopaminergic neurons in aging and in Parkinson disease, resulting in loss of mitochondrial function and, ultimately, neuronal death.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Ris
References
Kraytsberg, Y. et al. Nat. Genet. 38, 518–520 (2006).
Bender, A. et al. Nat. Genet. 38, 515–517 (2006).
Attardi, G. & Schatz, G. Annu. Rev. Cell Biol. 4, 289–333 (1988).
Dimauro, S. & Davidzon, G. Ann. Med. 37, 222–232 (2005).
Srivastava, S. & Moraes, C.T. Hum. Mol. Genet. 14, 893–902 (2005).
Corral-Debrinski, M. et al. Nat. Genet. 2, 324–329 (1992).
Rossignol, R. et al. Biochem. J. 370, 751–762 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Manfredi, G. mtDNA clock runs out for dopaminergic neurons. Nat Genet 38, 507–508 (2006). https://doi.org/10.1038/ng0506-507
Issue Date:
DOI: https://doi.org/10.1038/ng0506-507
This article is cited by
-
Genotype and phenotype analyses in 136 patients with single large-scale mitochondrial DNA deletions
Journal of Human Genetics (2008)
-
Localization of Abasic Sites and Single-Strand Breaks in Mitochondrial DNA from Brain of Aged Rat, Treated or not with Caloric Restriction Diet
Neurochemical Research (2008)
