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More to Hi-C than meets the eye

Nature Genetics volume 43, pages 1047–1048 (2011)Cite this article

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Diversification and specialization of high-throughput technologies demand assay-specific treatment of data for reliable interpretation. A new study shows that data generated using the Hi-C approach contain hidden features of interchromosomal DNA interactions, which are revealed through analysis with an integrated probabilistic model that corrects for multiple sources of bias in the data.

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Figure 1: Correcting Hi-C data for systematic biases and subsequent analyses suggest that DNase I hypersensitivity is most directly correlated with physical DNA interactions.

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Authors and Affiliations

  1. Myong-Hee Sung and Gordon L. Hager are at the Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.,

    Myong-Hee Sung & Gordon L Hager

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  1. Myong-Hee Sung
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  2. Gordon L Hager
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Correspondence to Gordon L Hager.

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The authors declare no competing financial interests.

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Sung, MH., Hager, G. More to Hi-C than meets the eye. Nat Genet 43, 1047–1048 (2011). https://doi.org/10.1038/ng.984

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