Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Changes in the Adenylate Energy Charge in Human Blood Platelets induced by Adenosine Diphosphate

Nature New Biology volume 243, pages 220–222 (1973)Cite this article

Abstract

WHEN platelet rich plasma at 37° C is exposed to low concentrations of adenosine diphosphate (ADP) the platelets change in shape from flat disks to irregular spheres1, and if the mixture is stirred and provided that necessary cofactors including calcium ions and fibrinogen are present, aggregation then takes place. The detailed mechanism of this response to ADP is the subject of a number of speculative hypotheses2–5. Here I report an observation on the effects of exogenous ADP on platelet adenine nucleotide metabolism that may be relevant to the induction of platelet aggregation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. MacMillan, D. C., and Oliver, M. F., J. Atheroscler. Res., 5, 440 (1965).

    Article  CAS  Google Scholar 

  2. Gaarder, A., and Laland, S., Nature, 202, 909 (1964).

    Article  CAS  Google Scholar 

  3. Spaet, T. H., and Lejnieks, I., Thromb. Diath. Haemorrh., 15, 36 (1966).

    Article  CAS  Google Scholar 

  4. Salzman, E. W., Chambers, D. A., and Neri, L. L., Nature, 210, 167 (1966).

    Article  CAS  Google Scholar 

  5. Booyse, F. M., and Rafelson, M. E., Blood, 33, 100 (1969).

    CAS  PubMed  Google Scholar 

  6. Ball, G., Fulwood, M., Ireland, D. M., and Yates, P., Biochem. J., 114, 669 (1969).

    Article  CAS  Google Scholar 

  7. Holmsen, H., Scand. J. Clin. Lab. Invest., 17, 537 (1965).

    Article  CAS  Google Scholar 

  8. Mills, D. C. B., and Roberts, G. C. K., J. Physiol., 193, 443 (1967).

    Article  CAS  Google Scholar 

  9. Ireland, D. M., and Mills, D. C. B., Biochem. J., 99, 283 (1966).

    Article  CAS  Google Scholar 

  10. Randerath, K., and Struck, H., J. Chromatog., 6, 365 (1961).

    Article  CAS  Google Scholar 

  11. Atkinson, D. E., Biochemistry, 7, 4030 (1968).

    Article  CAS  Google Scholar 

  12. Thompson, F. M., and Atkinson, D. E., Biochem. Biophys. Res. Comm., 45, 1561 (1971).

    Article  Google Scholar 

  13. Michal, F., and Born, G. V. R., Nature New Biology, 231, 220 (1971).

    Article  CAS  Google Scholar 

  14. O'Brien, J. R., Nature, 207, 306 (1965).

    Article  CAS  Google Scholar 

  15. Mürer, E. H., Hellem, A. J., and Rozenberg, M. C., Scand. J. Clin. Lab. Invest., 19, 280 (1967).

    Article  Google Scholar 

  16. Born, G. V. R., Foulks, J., Michal, F., and Sharp, D. E., J. Physiol., 225, 27P (1972).

    CAS  PubMed  Google Scholar 

  17. Hovig, T., Ser. Haematol., 2, 3 (1968).

    Google Scholar 

  18. White, J. G., Blood, 31, 604 (1968).

    CAS  PubMed  Google Scholar 

  19. Doery, J. C. G., Hirsh, J., and Cooper, I., Blood, 36, 159 (1970).

    CAS  PubMed  Google Scholar 

  20. Mills, D. C. B., and Thomas, D. P., Nature, 222, 991 (1969).

    Article  CAS  Google Scholar 

  21. Holmsen, H., Clin. Hematol., 1, 235 (1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thrombosis Research Center, Temple University Hospital Medical School, Philadelphia, Pennsylvania, 19140

    D. C. B. MILLS

Authors
  1. D. C. B. MILLS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MILLS, D. Changes in the Adenylate Energy Charge in Human Blood Platelets induced by Adenosine Diphosphate. Nature New Biology 243, 220–222 (1973). https://doi.org/10.1038/newbio243220a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio243220a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing