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Optical and Pharmacological Stimulation of Visual Cortical Neurones

Nature New Biology volume 242, pages 210–212 (1973)Cite this article

Abstract

Krnjević and Phillis1,2 and others3,1 have reported that only about 10–20% of all cerebral cortical neurones can be influenced by the micro-iontophoretic administration of acetylcholine (ACh). Neurones excited by this substance were probably all pyramidal cells in the deeper layers of the cortex, but cells inhibited by ACh were often found in the more superficial layers4. That excitability by ACh is peculiar to a restricted class of neurones could mean that these cells receive synaptic connexions from a specialized pathway which is not shared by the remainder of the cortical cell population and which path could determine their functional role.

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References

  1. Krnjević, K., and Phillis, J. W., J. Physiol., 165, 274 (1963).

    Article  Google Scholar 

  2. Krnjević, K., and Phillis, J. W., J. Physiol., 166, 296 (1963).

    Article  Google Scholar 

  3. Spehlmann, R., J. Neurophysiol., 26, 127 (1963).

    Article  CAS  Google Scholar 

  4. Phillis, J. W., The Pharmacology of Synapses (Pergamon, Oxford 1970).

    Google Scholar 

  5. Hubel, D. H., and Wiesel, T. N., J. Physiol., 148, 574 (1959).

    Article  CAS  Google Scholar 

  6. Hubel, D. H., and Wiesel, T. N., J. Physiol., 160, 106 (1962).

    Article  CAS  Google Scholar 

  7. Hubel, D. H., and Wiesel, T. N., J. Physiol., 195, 215 (1968).

    Article  CAS  Google Scholar 

  8. Baumgartner, G., Brown, J. L., and Schulz, A., J. Neurophysiol., 28, 1 (1965).

    Article  CAS  Google Scholar 

  9. Wurtz, R. H., J. Neurophysiol., 32, 727 (1969).

    Article  CAS  Google Scholar 

  10. Bishop, P. O., in The Neurosciences (edit. by Schmitt, F. O.), 2, 471 (Rockefeller University Press, New York, 1970).

    Google Scholar 

  11. Poggio, G. F., Invest. Ophthalm., 11, 368 (1972).

    CAS  Google Scholar 

  12. Pettigrew, J. D., Nikara, T., and Bishop, P. O., Exp. Brain Res., 6, 373 (1968).

    CAS  PubMed  Google Scholar 

  13. Eccles, J. C., Schmidt, R. F., and Willis, W. D., J. Physiol., 168, 500 (1963).

    Article  CAS  Google Scholar 

  14. Barker, J. L., and Nicoll, R. A., Science, 176, 1043 (1972).

    Article  CAS  Google Scholar 

  15. Davidson, N., and Southwick, C. A., J. Physiol., 219, 689 (1971).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology and Pharmacology and Department of Psychology, Duke University, Durham, North Carolina, 27710

    E. WALLINGFORD, R. OSTDAHL, P. ZARZECKI, P. KAUFMAN & G. SOMJEN

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  1. E. WALLINGFORD
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  2. R. OSTDAHL
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  3. P. ZARZECKI
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  4. P. KAUFMAN
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  5. G. SOMJEN
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WALLINGFORD, E., OSTDAHL, R., ZARZECKI, P. et al. Optical and Pharmacological Stimulation of Visual Cortical Neurones. Nature New Biology 242, 210–212 (1973). https://doi.org/10.1038/newbio242210a0

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