Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Water-soluble and Lipid-free Fraction from BCG with Adjuvant and Antitumour Activity

Nature New Biology volume 238, pages 241–242 (1972)Cite this article

Abstract

BCG has been used to influence immune responses1,2, but water insolubility and difficulty in administration have limited its use. Furthermore, the complexity of BCG causes various biological side effects that render the interpretation of results imprecise. I have isolated a fully water-soluble lipid-free fraction from BCG, called MAAF. This is not toxic and stimulates cell-mediated and humoral immune responses. The administration of MAAF with killed leukaemic cells (by irradiation) to mice receiving 104 viable L 1210 leukaemic cells inhibited the development of tumours such that 90% of the mice survived.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Biozzi, C., Stiffel, C., Halperne, B. N., and Mouton, D., CR Soc. Biol., 153, 987 (1959).

    CAS  Google Scholar 

  2. Mathé, G., Pouillard, P., and Lapeyraque, F., Brit. J. Cancer, 23, 814 (1969).

    Article  Google Scholar 

  3. Jerne, N. K., and Nordin, A. A., Science, 140, 405 (1963).

    Article  Google Scholar 

  4. Brian, B. L., and Gardner, E. W., J. Infect. Diseases, 118, 47 (1968).

    Article  CAS  Google Scholar 

  5. Anderson, R. J., Yale J. Biol. Med., 15, 311 (1943).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Raffel, S., Experientia, 6, 410 (1950).

    Article  CAS  Google Scholar 

  7. Hiu, I. J., and Amiel, J. L., J. Gen. Microbiol., 66, 239 (1971).

    Article  CAS  Google Scholar 

  8. Hiu, I. J., Amiel, J. L., and Nikdjou, K., Europ. J. Clin. Biol. Res., 15, 887 (1970).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut de Cancérologie et d'Immunogéenéetique, Hôpital Paul-Brousse, 14 and 16 Avenue Paul-Vaillant-Couturier, 94, Villejuif

    I. J. HIU

Authors
  1. I. J. HIU
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HIU, I. Water-soluble and Lipid-free Fraction from BCG with Adjuvant and Antitumour Activity. Nature New Biology 238, 241–242 (1972). https://doi.org/10.1038/newbio238241a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio238241a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing