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Spin Immunoassay Technique for Determination of Morphine

Nature New Biology volume 236, pages 93–94 (1972)Cite this article

Abstract

GENERAL techniques available for the assay of discrete chemical entities in biological fluids are inadequate. An ideal assay technique should provide rapid and accurate molecular recognition (specificity), high sensitivity, simplicity in execution, and adaptability to large classes of compounds. This report describes a general immunoassay method (referred to as “FRATtm”, free radical assay technique1) which has all these advantages without the radiation hazards and manipulative disadvantages of other immunoassay techniques.

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References

  1. Chemistry and Engineering News, 49, 11 (1971).

  2. McConnell, H. M., and McFarland, B. G., Quart. Rev. Biophys., 3, 91 (1970).

    Article  CAS  Google Scholar 

  3. Stryer, L., and Griffith, O. H., Proc. US Nat. Acad. Sci., 54, 1785 (1965); Hsia, J. C., and Piette, L. H., Arch. Biochem. Biophys., 132, 466 (1969).

    Article  CAS  Google Scholar 

  4. German Patent No. 116806 (1899).

  5. Spector, S., and Parker, C. W., Science, 168, 1347 (1970).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Syva (formerly Synvar) Research Institute, Palo Alto, California, 94304

    RICHARD K. LEUTE & EDWIN F. ULLMAN

  2. Stanford University Medical School, Stanford, California, 94305

    AVRAM GOLDSTEIN & LEONARD A. HERZENBERG

Authors
  1. RICHARD K. LEUTE
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  2. EDWIN F. ULLMAN
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  3. AVRAM GOLDSTEIN
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  4. LEONARD A. HERZENBERG
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LEUTE, R., ULLMAN, E., GOLDSTEIN, A. et al. Spin Immunoassay Technique for Determination of Morphine. Nature New Biology 236, 93–94 (1972). https://doi.org/10.1038/newbio236093a0

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  • DOI: https://doi.org/10.1038/newbio236093a0

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