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Association of Viral Reverse Transcriptase with an Enzyme degrading the RNA Moiety of RNA-DNA Hybrids

Nature New Biology volume 234, pages 240–243 (1971)Cite this article

Abstract

DURING replication of RNA tumour viruses, the genetic information contained in the viral RNA seems to be transferred to DNA1,2. Studies on the enzymatic activities present in the virus particles suggest that this transfer is mediated by an RNA dependent DNA polymerase3,4. RNA-DNA hybrids have been demonstrated to occur as intermediates in this reaction5, and single stranded DNA is generated as an early reaction product6, which is then replicated to give a double stranded DNA product6–8. The mechanism by which the single stranded DNA is displaced from the RNA template is, however, not known.

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Authors and Affiliations

  1. Max-Planck-Institut für Virusforschung, Tübingen

    K. MÖLLING, D. P. BOLOGNESI & H. BAUER

  2. Max-Planck-Institut für Biologie, Tübingen

    W. BÜSEN, H. W. PLASSMANN & P. HAUSEN

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  1. K. MÖLLING
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MÖLLING, K., BOLOGNESI, D., BAUER, H. et al. Association of Viral Reverse Transcriptase with an Enzyme degrading the RNA Moiety of RNA-DNA Hybrids. Nature New Biology 234, 240–243 (1971). https://doi.org/10.1038/newbio234240a0

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