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Chronic nonmalignant pain: a challenge for patients and clinicians

Abstract

Chronic pain is widely regarded as a condition that is triggered by various factors, including physical, socio-cultural and psychological deficiencies (that is, maladaptive beliefs). These factors are important in the development and maintenance of this unpleasant experience, which consequently requires a biopsychosocial treatment approach. Pain is a multifaceted sense, the perception of which is personal. Pain also depends on various circumstances, and therefore represents a challenge for the patient, as well for the treating physicians. Patients who suffer from long-lasting pain with a predominantly psychosocial component should be referred to specialized pain clinics for further diagnostic assessment and possible allocation to multidisciplinary pain programs. High-quality randomized controlled trials indicate that multidisciplinary pain programs represent the best therapeutic option for the management of patients with complaints associated with complex chronic pain. The prevalence and the costs—both direct and indirect—that are attributed to chronic pain are increasing; however, not enough is being done to sufficiently and effectively treat chronic pain. There is, therefore, a need for well-designed, interdisciplinary, internationally comparable, and widely distributed pain programs, both in outpatient and inpatient settings, to contribute to the prevention of some future pain diseases.

Key Points

  • A multidisciplinary approach to treating pain represents a valid, evidence-based treatment modality for patients with chronic pain

  • Multidisciplinary pain programs should ideally involve a physician, a physiotherapist, a psychologist, an occupational therapist and a social worker to cover the main areas of treatment of chronic pain based on the biopsychosocial model of illness

  • The primary aims of pain programs are to improve the health-related quality of life and to teach the patient how to accept and cope with pain

  • Pre-existing psychological vulnerabilities and high psychosocial distress should be considered in the comprehensive assessment of patients with chronic pain before embarking on a pain management program

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References

  1. Meeus M and Nijs J (2007) Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. J Clin Rheumatol 26: 465–473

    Article  Google Scholar 

  2. Staud R (2002) Evidence of involvement of central neural mechanisms in generating fibromyalgia pain. Curr Rheumatol Rep 4: 299–305

    Article  Google Scholar 

  3. Dersh J et al. (2002) Chronic pain and psychopathology: research findings and theoretical considerations. Psychosom Med 64: 773–786

    PubMed  Google Scholar 

  4. Merskey H and Bogduk N (1994) Classification of chronic pain. Descriptions of chronic pain syndromes and definition of pain terms. Seattle: IASP Editions

    Google Scholar 

  5. Waddell G (1987) 1987 Volvo award in clinical sciences. A new clinical model for the treatment of low-back pain. Spine 12: 632–644

    Article  CAS  Google Scholar 

  6. Ostelo RW et al. (2000) Behavioral-graded activity compared with usual care after first-time disk surgery: considerations of the design of a randomized clinical trial. J Manipulative Physiol Ther 23: 312–319

    CAS  PubMed  Google Scholar 

  7. Stanos S and Houle TT (2006) Multidisciplinary and interdisciplinary management of chronic pain. Phys Med Rehabil Clin N Am 17: 435–450

    Article  Google Scholar 

  8. Gatchel RJ and Okifuji A (2006) Evidence-based scientific data documenting the treatment and cost-effectiveness of comprehensive pain programs for chronic nonmalignant pain. J Pain 7: 779–793

    Article  Google Scholar 

  9. Bergman S (2005) Psychosocial aspects of chronic widespread pain and fibromyalgia. Dis Rehabil 27: 675–683

    Article  Google Scholar 

  10. Cedraschi C et al. (2004) Fibromyalgia: a randomised, controlled trial of a treatment programme based on self management. Ann Rheum Dis 63: 290–296

    Article  CAS  Google Scholar 

  11. Jensen IB et al. (1997) Treatment for “helpless” women suffering from chronic spinal pain: a randomized controlled 18-month follow-up study. J Occ Rehabil 7: 225–238

    Article  Google Scholar 

  12. Kaapa EH et al. (2006) Multidisciplinary group rehabilitation versus individual physiotherapy for chronic nonspecific low back pain: a randomized trial. Spine 31: 371–376

    Article  Google Scholar 

  13. Kole-Snijders AM et al. (1999) Chronic low-back pain: what does cognitive coping skills training add to operant behavioral treatment? Results of a randomized clinical trial. J Consult Clin Psychol 67: 931–944

    Article  CAS  Google Scholar 

  14. Lemstra M and Olszynski WP (2005) The effectiveness of multidisciplinary rehabilitation in the treatment of fibromyalgia: a randomized controlled trial. Clin J Pain 21: 166–174

    Article  Google Scholar 

  15. Spinhoven P et al. (2004) Catastrophizing and internal pain control as mediators of outcome in the multidisciplinary treatment of chronic low back pain. Eur J Pain 8: 211–219

    Article  Google Scholar 

  16. Smith BH et al. (2001) The impact of chronic pain in the community. Fam Pract 18: 292–299

    Article  CAS  Google Scholar 

  17. Urwin M et al. (1998) Estimating the burden of musculoskeletal disorders in the community: the comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation. Ann Rheum Dis 57: 649–655

    Article  CAS  Google Scholar 

  18. Centers for Disease Control and Prevention (2001) Prevalence of disabilities and associated health conditions among adults—United States, 1999. Morb Mortal Wkly Rep 50: 120–125

  19. Breivik H et al. (2006) Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 10: 287–333

    Article  Google Scholar 

  20. Elliott AM et al. (1999) The epidemiology of chronic pain in the community. Lancet 354: 1248–1252

    Article  CAS  Google Scholar 

  21. Woolf AD and Pfleger B (2003) Burden of major musculoskeletal conditions. Bull World Health Organ 81: 646–656

    PubMed  PubMed Central  Google Scholar 

  22. Salovey P et al. (1992) Reporting chronic pain episodes on health surveys. In Vital Health Statistics, series 6 (DHHS publication no. PHS 92-1081). Washington, DC: National Center for Health Statistics.

    Google Scholar 

  23. Smith BH et al. (2004) Is chronic pain a distinct diagnosis in primary care? Evidence arising from the Royal College of General Practitioners' Oral Contraception study. Fam Pract 21: 66–74

    Article  Google Scholar 

  24. Gatchel RJ et al. (1994) Psychopathology and the rehabilitation of patients with chronic low back pain disability. Arch Phys Med Rehabil 75: 666–670

    Article  CAS  Google Scholar 

  25. Smith BH et al. (2007) Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. Clin J Pain 23: 143–149

    Article  Google Scholar 

  26. Riedel W and Neeck G (2001) Nociception, pain, and antinociception: current concepts. Z Rheumatol 60: 404–415

    Article  CAS  Google Scholar 

  27. Olason M (2004) Outcome of an interdisciplinary pain management program in a rehabilitation clinic. Work 22: 9–15

    PubMed  Google Scholar 

  28. Guzman J et al.: Multidisciplinary bio-psycho-social rehabilitation for chronic low back pain. Cochrane Database of Systematic Reviews 2006, Issue 2. Art. No.: CD000963. 10.1002/14651858.CD000963.pub2

    Google Scholar 

  29. Fishman P et al. (1997) Chronic care costs in managed care. Health Aff 16: 239–247

    Article  CAS  Google Scholar 

  30. Aronoff G et al. (2000) Biopsychosocial evaluation and treatment of chronic pain. In Practical Management of Pain, 156–165 (Eds Raj P et al.) St Louis: Mosby, Inc.

    Google Scholar 

  31. Pfingsten M et al. (1997) Multidisciplinary treatment program on chronic low back pain, part 4. Prognosis of treatment outcome and final conclusions. Schmerz 11: 30–41

    Article  CAS  Google Scholar 

  32. Michaelson P et al. (2004) Factors predicting pain reduction in chronic back and neck pain after multimodal treatment. Clin J Pain 20: 447–454

    Article  Google Scholar 

  33. Edwards RR et al. (2003) Pain tolerance as a predictor of outcome following multidisciplinary treatment for chronic pain: differential effects as a function of sex. Pain 106: 419–426

    Article  Google Scholar 

  34. Keogh E et al. (2005) Do men and women differ in their response to interdisciplinary chronic pain management? Pain 114: 37–46

    Article  Google Scholar 

  35. Vowles KE et al. (2004) Predicting work status following interdisciplinary treatment for chronic pain. Eur J Pain 8: 351–358

    Article  Google Scholar 

  36. Smith MT et al. (2004) Suicidal ideation in outpatients with chronic musculoskeletal pain: an exploratory study of the role of sleep onset insomnia and pain intensity. Clin J Pain 20: 111–118

    Article  Google Scholar 

  37. Smith B and Gribbin M (2001) Etiology, prevention, treatment, and disability management of chronic pain. Introduction. Clin J Pain 17: S1–S4

    Article  CAS  Google Scholar 

  38. Schrieber L and Colley M (2004) Patient education. Best Pract Res Clin Rheumatol 18: 465–476

    Article  Google Scholar 

  39. Moseley GL et al. (2004) A randomized controlled trial of intensive neurophysiology education in chronic low back pain. Clin J Pain 20: 324–330

    Article  Google Scholar 

  40. McCracken LM et al. (2004) Acceptance of chronic pain: component analysis and a revised assessment method. Pain 107: 159–166

    Article  Google Scholar 

  41. Sullivan MJ et al. (2001) Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain 17: 52–64

    Article  CAS  Google Scholar 

  42. Lazarus R and Folkman S (1984) Stress, Appraisal, and Coping. New York: Springer Verlag

    Google Scholar 

  43. Leeuw M et al. (2007) The fear-avoidance model of musculoskeletal pain: current state of scientific evidence. J Behav Med 30: 77–94

    Article  Google Scholar 

  44. Brook S (2002) Improving fitness and function in complex regional pain syndrome. In Topical Issues in Pain 3, 161–171 (Ed. Gifford L) Falmouth, UK: CNS Press

  45. Fey SG and Fordyce WE (1983) Behavioral rehabilitation of the chronic pain patient. Ann Rev Rehabil 3: 32–63

    CAS  Google Scholar 

  46. Ettinger AB and Argoff CE (2007) Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain. Neurotherapeutics 4: 75–83

    Article  CAS  Google Scholar 

  47. Wood PB et al. (2007) Novel pharmacotherapy for fibromyalgia. Expert Opin Investig Drugs 16: 829–841

    Article  CAS  Google Scholar 

  48. Geiser D (1992) A comparison of acceptance-focused and control-focused psychological treatments in a chronic pain treatment center [doctoral dissertation]. Reno: University of Nevada-Reno

    Google Scholar 

  49. McCracken LM and Eccleston C (2006) A comparison of the relative utility of coping and acceptance-based measures in a sample of chronic pain sufferers. Eur J Pain 10: 23–29

    Article  Google Scholar 

  50. Boutron I et al. (2005) A checklist to evaluate a report of a nonpharmacological trial (CLEAR NPT) was developed using consensus. J Clin Epidemiol 58: 1233–1240

    Article  Google Scholar 

  51. Jensen IB et al. (2001) A randomized controlled component analysis of a behavioral medicine rehabilitation program for chronic spinal pain: are the effects dependent on gender? Pain 91: 65–78

    Article  CAS  Google Scholar 

  52. Jensen IB et al. (2005) A 3-year follow-up of a multidisciplinary rehabilitation programme for back and neck pain. Pain 115: 273–283

    Article  Google Scholar 

  53. Bennett R and Nelson D (2006) Cognitive behavioral therapy for fibromyalgia. Nat Clin Pract Rheumatol 2: 416–424

    Article  Google Scholar 

  54. Dersh J et al. (2004) The management of secondary gain and loss in medicolegal settings: strengths and weaknesses. J Occup Rehabil 14: 267–279

    Article  Google Scholar 

  55. Wilder-Smith OH et al. (2001) The management of chronic pain in Switzerland: a comparative survey of Swiss medical specialists treating chronic pain. Eur J Pain 5: 285–298

    Article  CAS  Google Scholar 

Download references

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Correspondence to Luca Scascighini.

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Scascighini, L., Sprott, H. Chronic nonmalignant pain: a challenge for patients and clinicians. Nat Rev Rheumatol 4, 74–81 (2008). https://doi.org/10.1038/ncprheum0680

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