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Fumarate in DNA repair

Nature Cell Biology volume 17, pages 1096–1097 (2015)Cite this article

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A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.

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Figure 1: Fumarase interacts with H2A.Z to promote NHEJ

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Authors and Affiliations

  1. Susan P. Lees-Miller is in the Departments of Biochemistry & Molecular Biology and Oncology, Robson DNA Science Centre, Southern Alberta Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada,

    Susan P. Lees-Miller

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  1. Susan P. Lees-Miller
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Correspondence to Susan P. Lees-Miller.

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The author declares no competing financial interests.

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Lees-Miller, S. Fumarate in DNA repair. Nat Cell Biol 17, 1096–1097 (2015). https://doi.org/10.1038/ncb3232

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