Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
Molecular Cancer Open Access 01 July 2023
-
Influence of the human papillomavirus on the radio-responsiveness of cancer stem cells in head and neck cancers
Scientific Reports Open Access 17 February 2020
-
Overexpression of microRNA-21 strengthens stem cell-like characteristics in a hepatocellular carcinoma cell line
World Journal of Surgical Oncology Open Access 28 October 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gómez-López, S., Lerner, R. G. & Petritsch, C. Cell Mol. Life Sci. 71, 575–597 (2013).
Troy, A. et al. Cell Stem Cell 11, 541–553 (2012).
Hwang, W-L. et al. Nat. Cell Biol. 16, 268–280 (2014).
Clevers, H. Cell 154, 274–284 (2013).
Quyn, A. J. et al. Cell Stem Cell 6, 175–181 (2010).
Snippert, H. J. et al. Cell 143, 134–144 (2010).
Itzkovitz, S., Blat, I. C., Jacks, T., Clevers, H. & van Oudenaarden, A. Cell 148, 608–619 (2012).
Kinzler, K. W. & Vogelstein, B. Cell 87, 159–170 (1996).
Barker, N. et al. Nature 457, 608–611 (2009).
Miyamoto, S. & Rosenberg, D. W. Cancer Sci. 102, 1938–1942 (2011).
O'Brien, C. A. et al. Cancer Cell 21, 777–792 (2012).
Bu, P. et al. Cell Stem Cell 12, 602–615 (2013).
Hermeking, H. Cell Death Differ. 17, 193–199 (2010).
Tam, W. L. & Weinberg, R. A. Nat. Med. 19, 1438–49 (2013).
Boman, B. M. & Huang, E. J. Clin. Oncol. 26, 2828–2838 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Lerner, R., Petritsch, C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol 16, 212–214 (2014). https://doi.org/10.1038/ncb2924
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2924
This article is cited by
-
Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
Molecular Cancer (2023)
-
Non-coding RNAs: the new central dogma of cancer biology
Science China Life Sciences (2021)
-
Influence of the human papillomavirus on the radio-responsiveness of cancer stem cells in head and neck cancers
Scientific Reports (2020)
-
Cancer stem cell fate determination: a nuclear phenomenon
The Nucleus (2019)
-
CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade
Gene Therapy (2018)
