Misfolded proteins are potentially toxic and are therefore subjected to highly selective degradation by the ubiquitin–proteasome system. The identification of the Hul5 ubiquitin ligase as a major mediator of such 'quality-control' ubiquitylation following heat shock raises new questions about the design of these pathways.
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Finley, D. Misfolded proteins driven to destruction by Hul5. Nat Cell Biol 13, 1290–1292 (2011). https://doi.org/10.1038/ncb2371
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DOI: https://doi.org/10.1038/ncb2371
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