Trans-tail regulation is the linked post-translational modification of tails on different histones. Two important studies implicate Swd2 as the link between H2B ubiquitylation and H3 methylation. Swd2 is a component of both the SET1 methyltransferase complex and the cleavage and polyadenylation factor CPF, implicating trans-tail regulation in differentiating events at the beginning and end of genes.
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References
Sun, Z. W. & Allis, C. D. Nature 418, 104–108 (2002).
Briggs, S. D. et al. Nature 418, 498 (2002).
Lee, J. S. et al. Cell 131, 1084–1096 (2007).
Vitaliano-Prunier, A. et al. Nature Cell Biol 10, 1365–1371 (2008).
Roguev, A. et al. EMBO J. 20, 7137–7148 (2001).
Nedea, E. et al. Mol Cell 29, 577–587 (2008).
Dichtl, B., Aasland, R. & Keller, W. RNA 10, 965–977 (2004).
Cheng, H., He, X. & Moore, C. Mol Cell Biol 24, 2932–2943 (2004).
Santos-Rosa, H. et al. Nature 419, 407–411 (2002).
Geng, F. & Tansey, W. P. Mol Biol Cell 19, 3616–3624 (2008).
Henry, K. W. et al. Genes Dev. 17, 2648–2663 (2003).
Dehe, P. M. et al. J Biol Chem 281, 35404–35412 (2006).
Kirmizis, A. et al. Nature 449, 928–932 (2007).
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Mellor, J. On your MARKS, get SET, METHYLATE!. Nat Cell Biol 10, 1249–1250 (2008). https://doi.org/10.1038/ncb1108-1249
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DOI: https://doi.org/10.1038/ncb1108-1249
