Signalling pathways controlling developmental cell fate rely on a variety of carbohydrate-based protein modifications, including glycosylation of cell-surface and extracellular-matrix proteins. Receptors themselves might be glycosylated during synthesis and secretory trafficking, regulating their subsequent signalling activities. Two recent reports have uncovered a shared requirement for nucleotide–sugar transport in these processes, underscoring the importance of carbohydrates in developmental patterning.
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Fortini, M. Sugar-coated pathways for developmental patterning. Nat Cell Biol 3, E229–E231 (2001). https://doi.org/10.1038/ncb1001-e229
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DOI: https://doi.org/10.1038/ncb1001-e229
