Tumorigenesis invariably requires multiple hits. New data shows that carcinogenesis originating from Ras mutations also requires increased Ras levels and a block of cellular senescence. Intriguingly, low non-transforming levels of Ras do not trigger senescence, suggesting that this programme is only activated in response to bona fide cancer threats.
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References
Michaloglou, C. et al. Nature 436, 720–724 (2005).
Xue, W. et al. Nature 445, 656–660 (2007).
Dimri, G. P. et al. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).
Collado, M. et al. Nature 436, 642 (2005).
Guerra, C. et al. Cancer Cell 4, 111–120 (2003).
Tuveson, D. A. et al. Cancer Cell 5, 375–387 (2004).
Sarkisian, C. J. et al. Nature Cell Biol. 9, 493–505 (2005).
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Cell 88, 593–602 (1997).
Mallette, F. A., Gaumont-Leclerc, M. F. & Ferbeyre, G. Genes Dev. 21, 43–48 (2007).
Bartkova, J. et al. Nature 444, 633–637 (2006).
Di Micco, R. et al. Nature 444, 638–642 (2006).
Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. Nature 322, 78–80 (1986).
Sun, P. et al. Cell 128, 295–308 (2007).
Johnson, S. M. et al. Cell 120, 635–647 (2005).
Narita, M. et al. Cell 113, 703–716 (2003).
Ferbeyre, G. et al. Genes Dev. 14, 2015–2027 (2000).
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Ferbeyre, G. Barriers to Ras transformation. Nat Cell Biol 9, 483–485 (2007). https://doi.org/10.1038/ncb0507-483
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DOI: https://doi.org/10.1038/ncb0507-483
