Experiments in the yeast Saccharomyces cerevisiae have shown that the enzyme Set1 preferentially targets the 5′ coding regions of transcriptionally active genes, where it catalyses di- and tri-methylation of histone H3 Lys 4. This methylation mark is retained after transcription has subsided, suggesting that it provides a memory of recent transcription.
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Turner, B. Memorable transcription. Nat Cell Biol 5, 390–393 (2003). https://doi.org/10.1038/ncb0503-390
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DOI: https://doi.org/10.1038/ncb0503-390
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