Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.
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Marshall, W. Cilia self-organize in response to planar cell polarity and flow. Nat Cell Biol 12, 314–315 (2010). https://doi.org/10.1038/ncb0410-314
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DOI: https://doi.org/10.1038/ncb0410-314
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