Bcl-2 and Bcl-xL perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-xL-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-xL to the correct cellular locations.
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References
Jacobson, M. D., Weil M. & Raff, M. C. Cell 88, 347–354 (1997).
Adrain, C. & Martin, S. J. Trends Biochem. Sci. 26, 319–323 (2001).
Martinou, J. C. & Green, D. R. Nature Rev. Mol. Cell Biol. 2, 63–67 (2001).
Kuwana, T. et al. Cell 111, 331–342 (2002).
Shirane, M. & Nakayama, K. I. Nature Cell Biol. 5, 28–37 (2003).
Yang, J. et al. Science 275, 1129–1132 (1997).
Cain, K., Brown, D. G., Langlais, C. & Cohen, G. M. J. Biol. Chem. 274, 22686–22692 (1999).
Gross, A., McDonnell, J. M. & Korsmeyer, S. J. Genes Dev. 13, 1899–1911 (1999).
Wei, M. C. et al. Science 292, 727–730 (2001).
Schiene-Fischer, C. & Yu, C. FEBS Lett. 495, 1–6 (2001).
Zacchi, P. et al. Nature 419, 853–857 (2002).
Wang, H. G. et al. Science 284, 339–343 (1999).
Shibasaki, F., Kondo, E., Akagi, T. & McKeon, F. Nature 386, 728–731 (1997).
Andreeva, L., Heads, R. & Green, C. J. Int. J. Exp. Path. 80, 305–315 (1999).
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Adrain, C., Creagh, E. & Martin, S. Defying death: showing Bcl-2 the way home. Nat Cell Biol 5, 9–11 (2003). https://doi.org/10.1038/ncb0103-9a
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DOI: https://doi.org/10.1038/ncb0103-9a
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