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Defying death: showing Bcl-2 the way home

Bcl-2 and Bcl-xL perform important functions in cell life or death decisions by setting the threshold for activation of the programmed cell death machinery. FKBP38, a member of the immunophilin family, has now been identified as a new Bcl-2/Bcl-xL-binding partner. Furthermore, FKBP38 seems to be crucial in targeting Bcl-2/Bcl-xL to the correct cellular locations.

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Figure 1: The mitochondrial apoptosome route to apoptosis.
Figure 2

References

  1. Jacobson, M. D., Weil M. & Raff, M. C. Cell 88, 347–354 (1997).

    Article  CAS  PubMed  Google Scholar 

  2. Adrain, C. & Martin, S. J. Trends Biochem. Sci. 26, 319–323 (2001).

    Article  Google Scholar 

  3. Martinou, J. C. & Green, D. R. Nature Rev. Mol. Cell Biol. 2, 63–67 (2001).

    Article  CAS  Google Scholar 

  4. Kuwana, T. et al. Cell 111, 331–342 (2002).

    Article  CAS  PubMed  Google Scholar 

  5. Shirane, M. & Nakayama, K. I. Nature Cell Biol. 5, 28–37 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Yang, J. et al. Science 275, 1129–1132 (1997).

    Article  CAS  PubMed  Google Scholar 

  7. Cain, K., Brown, D. G., Langlais, C. & Cohen, G. M. J. Biol. Chem. 274, 22686–22692 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Gross, A., McDonnell, J. M. & Korsmeyer, S. J. Genes Dev. 13, 1899–1911 (1999).

    Article  CAS  PubMed  Google Scholar 

  9. Wei, M. C. et al. Science 292, 727–730 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Schiene-Fischer, C. & Yu, C. FEBS Lett. 495, 1–6 (2001).

    Article  CAS  PubMed  Google Scholar 

  11. Zacchi, P. et al. Nature 419, 853–857 (2002).

    Article  CAS  PubMed  Google Scholar 

  12. Wang, H. G. et al. Science 284, 339–343 (1999).

    Article  CAS  PubMed  Google Scholar 

  13. Shibasaki, F., Kondo, E., Akagi, T. & McKeon, F. Nature 386, 728–731 (1997).

    Article  CAS  PubMed  Google Scholar 

  14. Andreeva, L., Heads, R. & Green, C. J. Int. J. Exp. Path. 80, 305–315 (1999).

    Article  CAS  Google Scholar 

Download references

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Adrain, C., Creagh, E. & Martin, S. Defying death: showing Bcl-2 the way home. Nat Cell Biol 5, 9–11 (2003). https://doi.org/10.1038/ncb0103-9a

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