ArticleAdrenocorticotropic hormone and 1,25-dihydroxyvitamin D3 enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes
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Adrenocorticotropic hormone and 1,25-dihydroxyvitaminD3 dramatically improve human osteoblast differentiation in vitro via synergistic mechanisms. Osteoblasts express the calcium sensing receptor and respond to calcium, but at non-physiological concentrations. Cortisol accelerates expression of some osteoblast-specific proteins, but blunts bone formation and other processes, and various hormone effects.
Supplementary information The online version of this article (doi:10.1038/labinvest.2017.62) contains supplementary material, which is available to authorized users.
© 2017 United States & Canadian Academy of Pathology.