Elsevier

Kidney International

Volume 78, Issue 6, 2 September 2010, Pages 535-537
Kidney International

Commentary
Lead-time bias in studies of cinacalcet prescriptions

https://doi.org/10.1038/ki.2010.220Get rights and content
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Observational studies have suggested a link between higher serum phosphate, calcium, parathyroid hormone levels, and cardiovascular mortality. The administration of cinacalcet has proven efficient in the treatment of secondary hyperparathyroidism among hemodialysis patients. In an observational study by Block et al., cinacalcet treatment is associated with a much improved all-cause and cardiovascular mortality. However, the results should be interpreted cautiously, as observational studies may be influenced by bias. This Commentary discusses the role of some common potential biases.

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The authors declared no competing interests.