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Influence of pre-pregnancy obesity on the development of macrosomia and large for gestational age in women with or without gestational diabetes mellitus in Chinese population

Journal of Perinatology volume 35, pages 985–990 (2015)Cite this article

Subjects

Abstract

Objective:

To determine the effects of gestational diabetes mellitus (GDM) and pre-pregnancy obesity on macrosomia and large for gestational age (LGA).

Study Design:

We conducted a prospective cohort study of 587 GDM women and 478 non-GDM women from 2012 to 2013. We collected their data of the pre-pregnancy weight, sociodemographic data, medical histories, clinical treatment, and followed-up the outcomes of delivery including birth weight. Multiple logistic regression models were used to test associations between pre-pregnant obesity and macrosomia/LGA and between GDM and macrosomia/LGA.

Result:

Of 1065 women we studied, obese women had 4.17 times and 2.27 times increased risk of developing macrosomia (95% CI: 2.52 to 6.91) and LGA (95% CI: 1.60 to 3.21), respectively, than non-obese women after adjustment for maternal age, gestational weeks and GDM. We did not find GDM is a risk factor for macrosomia or LGA after GDM treatment.

Conclusion:

Pre-pregnancy obesity accounts for a high prevalence of macrosomia. Interventions that focus on pre-pregnancy obesity have the potential to reach far more women at risk of macrosomia.

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Acknowledgements

This study was supported by a grant from the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20120001110014).

Author information

Author notes

  1. L-F Wang, H-J Wang and D Ao: These authors contributed equally to this work.

  2. Y Wang and H-X Yang: These two authors contributed equally to the manuscript.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China

    L-F Wang & H-X Yang

  2. Department of Child, Adolescent and Women’s Health, School of Public Health, Peking University Health Science Center, Beijing, China

    L-F Wang, H-J Wang, D Ao, Z Liu & Y Wang

  3. Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China

    H-J Wang, Z Liu & Y Wang

  4. Health Management Center, Xinjiang Medical University, Xinjiang, China

    D Ao

Authors
  1. L-F Wang
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  2. H-J Wang
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  3. D Ao
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  4. Z Liu
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  5. Y Wang
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Corresponding authors

Correspondence to Y Wang or H-X Yang.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on the Journal of Perinatology website

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Wang, LF., Wang, HJ., Ao, D. et al. Influence of pre-pregnancy obesity on the development of macrosomia and large for gestational age in women with or without gestational diabetes mellitus in Chinese population. J Perinatol 35, 985–990 (2015). https://doi.org/10.1038/jp.2015.119

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  • DOI: https://doi.org/10.1038/jp.2015.119

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