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  • Original Article
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Placental pathology and neonatal thrombocytopenia: lesion type is associated with increased risk

Journal of Perinatology volume 34, pages 914–916 (2014)Cite this article

Subjects

Abstract

Objective:

To investigate the association between thrombocytopenia and placental lesions.

Study Design:

Cases included singleton infants admitted to the intensive care unit (2005 to 2010) with platelet counts <100 000 μl−1. We selected a contemporaneous control group matched for gestational age: 49 cases and 63 controls. The frequency of thrombosis in fetal vessels, fetal thrombotic vasculopathy, acute chorioamnionitis, chronic villitis, infarcts, hematomas, cord insertion and increased circulating nucleated red blood cells were identified on retrospective review of placental histology. Logistic regression models were used to test for associations.

Result:

Placental lesions associated with poor maternal perfusion (odds ratio (OR) 3.36, 95% confidence interval (CI) 1.38, 8.15) or affecting fetal vasculature (OR 2.75, 95% CI 1.05, 7.23), but not inflammation, were associated with thrombocytopenia. A Pearson Chi-Square Test for Independence for fetal and maternal lesions indicated that the two are independent factors.

Conclusion:

Poor maternal perfusion and fetal vascular lesions are independently associated with thrombocytopenia in the newborn.

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References

  1. Christensen RD, Henry E, Wiedmeier SE, Stoddard RA, Sola-Visner MC, Lambert DK et al. Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol 2006; 26 (6): 348–353.

    Article  CAS  Google Scholar 

  2. Ulusoy E, Tufekci O, Duman N, Kumral A, Irken G, Oren H . Thrombocytopenia in neonates: causes and outcomes. Ann Hematol 2013; 92 (7): 961–967.

    Article  Google Scholar 

  3. Roberts I, Murray NA . Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed 2003; 88 (5): F359–F364.

    Article  CAS  Google Scholar 

  4. Chakravorty S, Roberts I . How I manage neonatal thrombocytopenia. Br J Haematol 2012; 156 (2): 155–162.

    Article  Google Scholar 

  5. Baer VL, Lambert DK, Henry E, Christensen RD . Severe thrombocytopenia in the NICU. Pediatrics 2009; 124 (6): e1095–e1100.

    Article  Google Scholar 

  6. Venkatesh V, Curley A, Clarke P, Watts T, Stanworth S . Do we know when to treat neonatal thrombocytopaenia? Arch Dis Child Fetal Neonatal Ed 2013; 98 (5): F380–F382.

    Article  Google Scholar 

  7. Salafia CM, Yampolsky M, Misra DP, Shlakhter O, Haas D, Eucker B et al. Placental surface shape, function, and effects of maternal and fetal vascular pathology. Placenta 2010; 31 (11): 958–962.

    Article  CAS  Google Scholar 

  8. Murray NA, Roberts IA . Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates. Pediatr Res 1996; 40 (1): 112–119.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA,

    J S Litt

  2. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA,

    J L Hecht

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  1. J S Litt
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  2. J L Hecht
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Correspondence to J L Hecht.

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The authors declare no conflict of interest.

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Litt, J., Hecht, J. Placental pathology and neonatal thrombocytopenia: lesion type is associated with increased risk. J Perinatol 34, 914–916 (2014). https://doi.org/10.1038/jp.2014.117

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  • DOI: https://doi.org/10.1038/jp.2014.117

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