Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • State of the Art
  • Published:

State-of-the-Art

Management of subsequent pregnancy after an unexplained stillbirth

Abstract

Purpose:

To review the management of pregnancy after an unexplained stillbirth.

Epidemiology:

Approximately 1 in 200 pregnancies will end in stillbirth, of which about one-third will remain unexplained. Unexplained stillbirth is the largest single contributor to perinatal mortality. Subsequent pregnancies do not appear to have an increased risk of stillbirth, but are characterized by increased rates of intervention (induction of labor, elective cesarean section) and iatrogenic adverse outcomes (low birth weight, prematurity, emergency cesarean section and post-partum hemorrhage).

Conclusions:

There is no level-one evidence to guide management in this situation. Pre-pregnancy counseling is very important to detect and correct potential risk factors such as obesity, smoking and maternal disease. As timely delivery is the mainstay of management, early accurate determination of gestational age is vital. There is controversy regarding the pattern of surveillance, but evidence exists only for ultrasound and not for regular non-stress testing, nor formal fetal movement charting. There is an urgent need for more studies in this important area.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Stanton C, Lawn J, Rahman H, Wilczynska-Ketende K, Hill K . Stillbirth rates: delivering estimates in 190 countries. Lancet 2006; 367: 1489–1494.

    Article  Google Scholar 

  2. Fretts RC . Etiology and prevention of stillbirth. Am J Obstet Gynecol 2005; 193: 1923–1935.

    Article  Google Scholar 

  3. Reddy UM . Prediction and prevention of recurrent stillbirth. Obstet Gynecol 2007; 110: 1151–1164.

    Article  Google Scholar 

  4. Silver RM . Fetal death. Obstet Gynecol 2007; 109: 153–167.

    Article  Google Scholar 

  5. Smith GCS, Fretts RC . Stillbirth. Lancet 2007; 370: 1715–1725.

    Article  Google Scholar 

  6. Sharma PP, Salihu HM, Oyelese Y, Ananth CV, Kirby RS . Is race a determinant of stillbirth recurrence? Obstet Gynecol 2006; 107: 391–397.

    Article  Google Scholar 

  7. Heinonen S, Kirkinen P . Pregnancy otucome after previous stillbirth resulting from causes other than maternal conditions and fetal abnormalities. Birth 2000; 27: 33–37.

    Article  CAS  Google Scholar 

  8. Robson S, Chan A, Keane RJ, Luke CG . Subsequent birth outcomes after an unexplained stillbirth: preliminary population-based retrospective cohort study. Aust NZ J Obstet Gynaecol 2001; 41: 29–34.

    Article  CAS  Google Scholar 

  9. Lurie S, Eldar I, Glezerman M, Sadan O . Pregnancy outcome after stillbirth. J Reprod Med 2007; 52: 289–292.

    PubMed  Google Scholar 

  10. Black M, Shetty A, Bhattacharya S . Obstetric outcomes subsequent to intrauterine death in the first pregnancy. Br J Obstet Gynaecol 2008; 115: 269–274.

    Article  CAS  Google Scholar 

  11. Robson S, Thompson J, Ellwood D . Obstetric management of the next pregnancy after an unexplained stillbirth: an anonymous postal survey of Australian obstetricians. Aust NZ J Obstet Gynaecol 2006; 46: 278–281.

    Article  Google Scholar 

  12. Vergani P, Cozzolino S, Pozzi E, Cuttin MS, Greco M, Ornaghi S et al. Identifying the causes of stillbirth: a comparison of four classification systems. Am J Obstet Gynecol 2008; 199: 319.e1–319.e4.

    Article  Google Scholar 

  13. Chan A, King JF, Flenady V, Haslam RH, Tudehope D . Classification of perinatal deaths: development of the Australian and New Zealand classifications. J Paediatr Child Health 2004; 40: 340–347.

    Article  CAS  Google Scholar 

  14. Measey MA, Charles A, d’Espaignet ET, Harrison C, Deklerk N, Douglass C . Aetiology of stillbirth: unexplored is not unexplained. Aust NZ J Public Health 2007; 31: 444–449.

    Article  Google Scholar 

  15. Yogev Y, Langer O . Recurrence of gestational diabetes: pregnancy outcome and birth weight diversity. J Matern Fetal Neonatal Med 2004; 15: 56–60.

    Article  CAS  Google Scholar 

  16. Preston FE, Rosendaal FR, Walker ID, Briet E, Berntorp E, Conard J et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 111–117.

    Article  Google Scholar 

  17. Saade F, McLintock C . Inherited thrombophilia and stillbirth. Semin Perinatol 2002; 26: 51–69.

    Article  Google Scholar 

  18. Mascola MA, Repke JT . Obstetric management of the high-risk lupus pregnancy. Rheum Dis Clin North Am 1997; 23: 119–132.

    Article  CAS  Google Scholar 

  19. Simpson L . Maternal medical disease: risk of antepartum fetal death. Semin Perinatol 2002; 26: 42–50.

    Article  Google Scholar 

  20. Baud D, Regan L, Greub G . Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis 2008; 21: 70–76.

    Article  Google Scholar 

  21. Xiong X, Buekens P, Fraser WD, Beck J, Offenbacher S . Periodontal disease and adverse pregnancy outcomes: a systematic review. Br J Obstet Gynaecol 2006; 113: 135–143.

    Article  CAS  Google Scholar 

  22. Boggess KA, Madianos PN, Preisser JS, Moise KJ, Offenbacker S . Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits. Am J OBstet Gynecol 2005; 192: 554–557.

    Article  Google Scholar 

  23. Vintzeleos AM, Ananth CV, Smulian JC, Scorza WE, Knuppel RA . Prenatal care and black-white fetal death disparity in the United States: heterogeneity by high-risk conditions. Obstet Gynecol 2002; 99: 483–489.

    Google Scholar 

  24. Hodnett ED, Fredericks S . Support during pregnancy for women at increased risk of low birthweight babies. Cochrane Database of Systematic Reviews 2003 Issue 3. Article no. CD000198.

  25. Galtier F, Raingeard I, Renard E, Boulot P, Bringer J . Optimizing the outcome of pregnancy in obese women: from pregestational to long-term management. Diabetes Metab 2008; 34: 19–25.

    Article  CAS  Google Scholar 

  26. Kristensen J, Vestergaard M, Wisborg K, Kesmodel U, Secher NJ . Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG 2005; 112: 403–408.

    Article  Google Scholar 

  27. Gray AD, Power ML, Zinberg S, Schulkin J . Assessment and management of obesity. Obstet Gynecol Survey 2006; 61: 742–748.

    Article  Google Scholar 

  28. Catalano PM . Management of obesity in pregnancy. Obstet Gynecol 2007; 109: 419–433.

    Article  Google Scholar 

  29. Cnattingius S, Akre O, Lambe M, Ockene J, Granath F . Will an adverse pregnancy outcome influence the risk of continued smoking in the next pregnancy? Am J Obstet Gynecol 2006; 195: 1680–1686.

    Article  Google Scholar 

  30. West R, McNeill A, Raw M . Smoking cessation guidelines for health professionals: an update. Thorax 2000; 55: 987–999.

    Article  CAS  Google Scholar 

  31. Forrest G, Standish E, Baum J . Support after perinatal death: a study of support and counselling after perinatal bereavement. Br Med J 1982; 285: 1475–1479.

    Article  CAS  Google Scholar 

  32. Hughes P, Turton P, Evans C . Stillbirth as a risk factor for depression and anxiety in the subsequent pregnancy: cohort study. Br Med J 1999; 318: 1721–1724.

    Article  CAS  Google Scholar 

  33. Dayan J, Creveuil C, Marks MN, Conroy S, Herlicoviez M, Dreyfus M et al. Prenatal depression, prenatal anxiety, and spontaneous preterm birth: a prospective cohort study among women with early and regular care. Psychosom Med 2006; 68: 938–946.

    Article  Google Scholar 

  34. Britton JR . Maternal anxiety: course and antecedents during the early postpartum period. Depress Anxiety 2007; 25: 793–800.

    Article  Google Scholar 

  35. Littleton HL, Breitkopf CR, Berenson AB . Correlates of anxiety symptoms during pregnancy and association with perinatal outcomes: a meta-analysis. Am J Obstet Gynecol 2007; 196: 424–432.

    Article  Google Scholar 

  36. Orr ST, Reiter JP, Blazer DG, James SA . Maternal prenatal pregnancy-related anxiety and spontaneous preterm birth in Baltimore, Maryland. Psychosom Med 2007; 69: 566–570.

    Article  Google Scholar 

  37. Cox JL, Holden JM, Sagovsky R . Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 150: 782–786.

    Article  CAS  Google Scholar 

  38. Smith CGS . Estimating risks for perinatal death. Am J Obstet Gynecol 2005; 192: 17–22.

    Article  Google Scholar 

  39. Cotzias C, Paterson-Brown S, Fisk N . Prospective risk of unexplained stillbirth in singleton pregnancies at term: population-based analysis. Br Med J 1999; 319: 287–288.

    Article  CAS  Google Scholar 

  40. Fretts RC, Elkin EB, Myers ER, Heffner LJ . Should older women have antepartum testing to prevent unexplained stillbirth? Obstet Gynecol 2004; 104: 56–64.

    Article  Google Scholar 

  41. Heffner LJ, Elkin E, Fretts RC . Impact of labor induction, gestational age, and maternal age on cesarean delivery rates. Obstet Gynecol 2003; 102: 287–293.

    PubMed  Google Scholar 

  42. Ben-Haroush A, Yogev Y, Bar J, Glickman H, Kaplan B, Hod M . Indicated labor induction with vaginal prostaglandin E2 increases the risk of cesarean section even in multiparous women with no prior cesarean section. J Perinat Med 2004; 32: 31–36.

    Article  CAS  Google Scholar 

  43. Glantz JC . Elective induction vs spontaneous labor. Associations and outcomes. J Reprod Med 2005; 50: 235–240.

    PubMed  Google Scholar 

  44. Neilson JP . Ultrasound for fetal assessment in early pregnancy. Cochrane Database of Systematic Reviews 1998 Issue 4. Article no. CD000182.

  45. Warren JE, Silver RM . Genetics of pregnancy loss. Clin Obstet Gynecol 2008; 51: 84–95.

    Article  Google Scholar 

  46. Lister T, Frota-Pessoa O . Recurrence risks for Down syndrome. Hum Genet 1980; 55: 203–208.

    Article  CAS  Google Scholar 

  47. Steinberg C, Zackai E, Eunpu D, Mennuti M, Emanuel B . Recurrence rate for de novo 21q21q translocation Down syndrome: a study of 112 families. Am J Med Genet 1984; 17: 523–530.

    Article  CAS  Google Scholar 

  48. Ryynanen M, Leskinen S, Heinonen S, Kirkinen P . Recurrence risk of a serious, noninherited chromosomal abnormality. Fertil Steril 1997; 68: 439–442.

    Article  CAS  Google Scholar 

  49. Riley M, Halliday J . Birth Defects in Victoria 2001–2002. Victorian Perinatal Data Collection Unit, Victorian Government Department of Human Services: Melbourne, 2004.

    Google Scholar 

  50. Robson SJ, Leader LR, Bennett MJ, Dear KGB . Women's expectations of management in their next pregnancy after an unexplained stillbirth. An Internet-based empirical study. Aust NZ J Obstet Gynaecol 2009. (in press).

  51. Robson SJ, Leader LR, Bennett MJ, Dear KGB . Do women's perceptions of care at the time of unexplained stillbirth influence their wishes for management in subsequent pregnancy? An Internet-based empirical study. J Obstet Gynaecol Res 2009. (in press).

  52. Saflund K, Sjogren B, Wredling R . The role of caregivers after a stillbirth: views and experiences of parents. Birth 2004; 31: 132–137.

    Article  Google Scholar 

  53. Kady S, Gardosi J . Perinatal mortality and fetal growth restriction. Best Pract Res Clin Obstet Gynaecol 2004; 18: 397–410.

    Article  Google Scholar 

  54. Saastad E, Vangen S, Frøen JF . Suboptimal care in stillbirths—a retrospective audit study. Acta Obstet Gynecol Scand 2007; 86: 444–450.

    Article  Google Scholar 

  55. Ong S, Danielian P . Unexplained stillbirths: are they preventable? Int J Gynaecol Obstet 2000; 69: 159.

    Article  CAS  Google Scholar 

  56. Weeks J, Asrat T, Morgan M, Nagoette M, Thomas SJ, Freeman RK . Antepartum surveillance for a history of stillbirth: when to begin? Am J Obstet Gynecol 1995; 172: 486–492.

    Article  CAS  Google Scholar 

  57. Onwude JL, Eisman V, Selo-Ojeme DO . Recurrent stillbirths: a matched case-control study of unexplained stillbirths at term. J Obstet Gynaecol 2006; 26: 205–207.

    Article  CAS  Google Scholar 

  58. Papageorghiou AT, Leslie K . Uterine artery Doppler in the prediction of adverse pregnancy outcome. Curr Opin Obstet Gynecol 2007; 19: 103–109.

    Article  Google Scholar 

  59. Smith GC, Yu CK, Papageorghiou AT, Cacho AM, Nicolaides KH . Maternal uterine artery Doppler flow velocimetry and the risk of stillbirth. Obstet Gynecol 2007; 109: 144–151.

    Article  Google Scholar 

  60. Neilson JP . Symphysis-fundal height measurement in pregnancy. Cochrane Database Syst Rev 2004 Issue 2. Article no. CD000944.

  61. Dudley NJ . A systematic review of the ultrasound estimation of fetal weight. Ultrasound Obstet Gynecol 2005; 25: 80–89.

    Article  CAS  Google Scholar 

  62. Clausson B, Gardosi J, Francis A, Cnattingius S . Perinatal outcome in SGA births defined by customised versus population-based birthweight standards. BJOG 2001; 108: 830–834.

    CAS  PubMed  Google Scholar 

  63. Warsof SL, Cooper DJ, Little D, Campbell S . Routine ultrasound screening for antenatal detection of intrauterine growth retardation. Obstet Gynecol 1986; 67: 33–39.

    CAS  PubMed  Google Scholar 

  64. Banks EH, Miller DA . Perinatal risks associated with borderline amniotic fluid index. Am J Obstet Gynecol 1999; 180: 1461–1463.

    Article  CAS  Google Scholar 

  65. Haram K, Säfteland E, Bukowski R . Intrauterine growth restriction. Int J Gynaecol Obstet 2006; 93: 5–12.

    Article  CAS  Google Scholar 

  66. Ayers S, Pickering AD . Psychological factors and ultrasound: differences between routine and high-risk scans. Ultrasound Obstet Gynecol 1997; 9: 76–79.

    Article  CAS  Google Scholar 

  67. Pattison N, McCowan L . Cardiotocography for antepartum fetal assessment. Cochrane Database Syst Rev 2000 Issue 2. Article no. CD001068.

  68. Heazell AEP, Froen JF . Methods of fetal movement counting and the detection of fetal compromise. J Obstet Gynaecol 2008; 28: 147–154.

    Article  CAS  Google Scholar 

  69. Froen JF, Arnestad M, Frey K, Vege A, Saugstad OD, Stray-Pedersen B . Risk factors for sudden intrauterine unexplained death: epidemiologic characteristics of singleton cases in Oslo, Norway, 1986–1995. Am J Obstet Gynecol 2001; 184: 694–702.

    Article  CAS  Google Scholar 

  70. Grant A, Elbourne D, Valentin L, Alexander S . Routine formal fetal movement counting and risk of antepartum late death in normally formed singletons. Lancet 1989; 2 (8659): 345–349.

    Article  CAS  Google Scholar 

  71. Harrington K, Thompson O, Jordan L, Page J, Carpenter RG, Campbell S . Obstetric outcome in women who present with a reduction in fetal movements in the third trimester of pregnancy. J Perinat Med 1998; 26: 77.

    Article  CAS  Google Scholar 

  72. Johnson RT, Jordan ET, Paine LL . Doppler recordings of fetal movement: II. Comparison with maternal perception. Obstet Gynecol 1990; 76: 42–43.

    CAS  PubMed  Google Scholar 

  73. Frøen JF . A kick from within—fetal movement counting and the cancelled progress in antenatal care. J Perinatal Med 2004; 32: 13–24.

    Article  Google Scholar 

  74. Yudkin P, Wood L, Redman C . Risk of unexplained stillbirth at different gestational ages. Lancet 1987; 1: 1192–1194.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S J Robson.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robson, S., Leader, L. Management of subsequent pregnancy after an unexplained stillbirth. J Perinatol 30, 305–310 (2010). https://doi.org/10.1038/jp.2009.133

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2009.133

Keywords

This article is cited by

Search

Quick links